Download PDF
Zeitschrift für Phytotherapie 2010; 31(3): 164-170
DOI: 10.1055/s-0030-1247663
Porträt Einer Arzneipflanze

© Hippokrates Verlag in MVS Medizinverlage Stuttgart GmbH & Co. KG

Agathosma betulina (Berg.) Pillans - der Buccostrauch

Klaus Peter Latté
Further Information

Publication History

Publication Date:
05 July 2010 (online)

    Permissions and Reprints

Zusammenfassung

Die Blattdroge von Agathosma betulina (Rutaceae) wird seit Langem von verschiedenen Eingeborenenstämmen in Südafrika als traditionelle Medizin zur Behandlung von Nieren- und Blasenerkrankungen, zur Entwässerung des Körpers und zur Behandlung von Entzündungen verwendet. Wichtigster Inhaltsstoff dieser Arzneipflanze ist das ätherische Öl, das durch Wasserdampfdestillation gewonnen wird und als Cassis-Aroma bekannt ist, mit einem hohen Anteil an Monoterpenen, wobei Monoterpen-Kohlenwasserstoffe und -Ketone mengenmäßig vorherrschen. Zusätzlich sind Flavonoide isoliert worden. Neuere pharmakologische Untersuchungen konnten antioxidative, schwache antimikrobielle sowie antiinflammatorische Wirkungen in vitro belegen. Bestimmte Blattextrakte zeigten in vitro pro-oxidative Aktivitäten und führten zu DNA-Schädigungen.

Summary

Agathosma betulina (Berg.) Pillans – wild buchu

The leaves of Agathosma betulina (Rutaceae) have been used for a long time by indigenous South Africans as a traditional remedy for the treatment of kidney- and bladder-disorders, fluid retention and inflammations. The essential oil, prepared by steam distillation of the leaves and known as “Cassis flavour”, consists of a high proportion of monoterpenes, especially monoterpenoid hydrocarbons and ketones. Beside the essential oil, flavonoids have been isolated from the leaves. Recent pharmacological studies demonstrate antioxidative, weak antimicrobial and also anti-inflammatory effects in vitro. First toxicological in vitro studies show DNA damages and pro-oxidative effects for certain leaf extracts.

Schlüsselwörter

Agathosma betulina - Barosma betulina - Rutaceae - Buccostrauch - ätherisches Öl - antioxidativ - antiinflammatorisch - Cassis-Aroma

Key words

Agathosma betulina - Barosma betulina - Rutaceae - essential oil - buchu - antioxidative - anti-inflammatory effect - Cassis flavour

Literatur

  • r1 [Anonymous]. Traditional medicines: Agathosma betulina herba. www.sahealthinfo.org/traditionalmeds/monographs/abetulina.htm Stand 15.09.2009.
  • r2 Badria FA.. Is man helpless against cancer? An environmental approach: antimutagenic agents from Egyptian food and medicinal preparations.  Cancer Lett. 1994;  84 1-5
    CrossrefPubMedGoogle Scholar
  • r3 Blommaert KLJ, Bartel E.. Chemotaxonomic aspects of the buchu species Agathosma betulina (Pillans) and Agathosma crenulata (Pillans) from local plantings.  J South Afr Bot. 1976;  42 121-126
    PubMedGoogle Scholar
  • r4 Collins NF, Graven EH.. Chemotaxonomy of commercial buchu species (Agathosma betulina and A. crenulata).  J Essential Oil Res. 1996;  8 229-335
    PubMedGoogle Scholar
  • r5 Feldman HS, Youngken HW.. A pharmacognostical study on buchu.  J Am Pharm Assoc. 1944;  33 277-288
    PubMedGoogle Scholar
  • r6 Fluck AJ, Mitchell WM, Perry HM.. Composition of buchu leaf oil.  J Sci Food Agric. 1961;  12 290-292
    CrossrefPubMedGoogle Scholar
  • r7 Gentry HS.. Buchu, a new cultivated crop in South Africa.  Econom Bot. 1961;  326-331
    PubMedGoogle Scholar
  • r8 Grange JM, Davey RW.. Detection of antituberculous activity in plants.  J Appl Bacteriol. 1990;  68 587-591
    PubMedGoogle Scholar
  • r9 Harvey RB.. A recent buchu adulteration.  J Am Pharm Assoc. 1913;  2 1305-1306
    PubMedGoogle Scholar
  • r10 Hoffmann-Bohm K.. Barosma betulina (Thunb.) Bartl. et Wendl. In: HagerRom 2006 Heidelberg; Springer Verlag
    PubMedGoogle Scholar
  • r11 Kaiser R, Lamparsky D, Schudel P.. Analysis of buchu leaf oil.  J Agric Food Chem. 1975;  23 943-950
    CrossrefPubMedGoogle Scholar
  • r12 Köhler FE.. Köhler's Medizinal-Pflanzen in naturgetreuen Abbildungen mit kurz erläuterndem Texte. Gera-Untermhaus: Fr. Eugen Köhler; 1887: Band 3, Monographie »Barosma betulina Bartling«
    PubMedGoogle Scholar
  • r13 Köpke T, Dietrich A, Mosandl A.. Chiral compounds of essential oils XIV: Simultaneous stereoanalysis of buchu leaf oil compounds.  Phytochem Anal. 1994;  5 61-67
    CrossrefPubMedGoogle Scholar
  • r14 Kommission E des Bundesgesundheitsamtes. Bucco-Blätter (Barosmae folium). Bundesanzeiger Nr. 22a, 1. Februar 1990
    Google Scholar
  • r15 Lamparsky D, Schudel P.. P-Menthane-8-thiol-3-one, a new component of buchu leaf oil.  Tetrahedr Lett. 1971;  36 3323-3326
    PubMedGoogle Scholar
  • r16 Lis-Balchin M, Hart S, Simpson E.. Buchu (Agathosma betulina and A. crenulata, Rutaceae) essential oils: their pharmacological action on guinea pig ileum and antimicrobial activity on micro-organism.  J Pharmacy and Pharmacol. 2000;  18 579-582
    PubMedGoogle Scholar
  • r17 Makunga NP, Philander LE, Smith M.. Current perspectives on an emerging formal natural products sector in South Africa.  J Ethnopharmacol. 2008;  119 365-375
    CrossrefPubMedGoogle Scholar
  • r18 Moolla A, van Vuuren SF, van Zyl RL, Viljoen AM.. Biological activity and toxicity profile of 17 Agathosma (Rutaceae) species.  South Afr J Bot. 2007;  73 588-592
    CrossrefPubMedGoogle Scholar
  • r19 Moolla A, Viljoen AM.. “Buchu” – Agathosma betulina and Agathosma crenulata (Rutaceae): A review.  J Ethnopharmacol. 2008;  119 413-419
    CrossrefPubMedGoogle Scholar
  • r20 Ntwana B.. Growth, mineral content and essential oil quality of buchu (Agathosma betulina) in response to pH under controlled conditions in comparison with plants from its natural habitat [Dissertation]. Stellenbosch University 2007
    PubMedGoogle Scholar
  • r21 Spreeth AD.. ′N hersening von die Agathosma-spesies van kommersiele belang.  J South Afr Bot. 1976;  42 109-119
    PubMedGoogle Scholar
  • r22 Steenkamp V.. Traditional herbal remedies used in South African women for gynaecological complaints.  J Ethnopharmacol. 2003;  86 97-108
    CrossrefPubMedGoogle Scholar
  • r23 Steenkamp V.. Phytomedicines for the prostate.  Fitoterapia. 2003;  74 545-552
    CrossrefPubMedGoogle Scholar
  • r24 Steenkamp V, Grimmer H, Semano M, Gulumian M.. Antioxidant and genotoxic properties of South African herbal extracts.  Mutat Res. 2005;  581 35-42
    PubMedGoogle Scholar
  • r25 Steenkamp V, Gouws MC, Gulumian M. , et al. Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatits.  J Ethnopharmacol. 2006;  103 71-75
    CrossrefPubMedGoogle Scholar
  • r26 Sundt E, Willhalm B, Chappaz R, Ohloff G.. Das organoleptische Prinzip von CassisFlavor im Buccusblätteröl.  Helv Chim Acta. 1971;  54 1801-1805
    CrossrefPubMedGoogle Scholar
  • r27 Thring TSA, Weitz FM.. Medicinal plant use in the Bredasdorp/Elim region of the Southern Overberg in the Western Cape Province of South Africa.  J Ethnopharmacol. 2006;  103 261-275
    CrossrefPubMedGoogle Scholar
  • r28 Thring TSA, Hili P, Naughton DP.. Anti-collagenase, anti-elastase and anti-oxidant activities of extracts from 21 plants.  BMC Compl Altern Med. 2009;  9 27
    PubMedGoogle Scholar
  • r29 van Wyk BE, van Oudtshoorn B, Gericke N.. Medicinal plants of South Africa. Pretoria; Briza Publications 1997
    PubMedGoogle Scholar
  • r30 van Wyk BE.. A review of Khoi-San and Cape Dutch medical ethnobotany.  J Ethnopharmacol. 2008;  119 331-341
    CrossrefPubMedGoogle Scholar
  • r31 Vermaak I, Viljoen AM, Hamman JH, van Vuuren SF.. The effect of simulated gastrointestinal conditions on the antimicrobial activity and chemical composition of indigenous South African plant extracts.  South Afr J Bot. 2009;  75 594-599
    CrossrefPubMedGoogle Scholar
  • r32 Viljoen AM, Moolla A, van Vuuren SF. , et al. The biological activity and essential oil composition of 17 Agathosma (Rutaceae) species.  J Essential Oil Res. 2006;  18 2-16
    PubMedGoogle Scholar
  • r33 Viljoen A, Moolla A.. Indigenous South African medicinal plants. Part 5: Agathosma betulina (“buchu”).  South Afr Pharm J. 2007;  74 (9) 39
    PubMedGoogle Scholar
  • r34 Watt C, Breyer-Brandwijk MG.. The medicinal and poisonous plants of southern and eastern Africa. Edinburgh, London; Livingstone 1962
    PubMedGoogle Scholar
  • r35 Wichtl M.. Teedrogen und Phytopharmaka. 5. Aufl. Stuttgart; Wissenschaftl. Verlagsges. 2009
    PubMedGoogle Scholar
  • r36 Williams S, Kepe T.. Discordant harvest: Debating the harvesting and commercialization of wild buchu (Agathosma betulina) in Elandskloof, South Africa.  Mountain Res Development. 2008;  28 58-64
    PubMedGoogle Scholar

Dr. Klaus Peter Latté

Warägerweg 21

13595 Berlin

Email: latte@zedat.fu-berlin.de

Online

http://dx.doi.org/10.1055/s-0030-1247663

      >