Dtsch Med Wochenschr 2010; 135(6): 256-259
DOI: 10.1055/s-0030-1247864
Arzneimittel & Pharmakotherapie | Review article
Angiologie
© Georg Thieme Verlag KG Stuttgart · New York

Dabigatran: eine neue Option zur Therapie und Prophylaxe thrombembolischer Erkrankungen?

Dabigatran: a new therapeutic option for therapy and prophylaxis of thromboembolic diseases?N. Gassanov1 , E. Caglayan1 , E. Erdmann1 , F. Er1
  • 1Klinik III für Innere Medizin, Herzzentrum der Universität zu Köln
Further Information

Publication History

eingereicht: 27.8.2009

akzeptiert: 26.11.2009

Publication Date:
26 January 2010 (online)

Literatur

  • 1 Blech S, Ebner T, Ludwig-Schwellinger E, Stangier J, Roth W. The metabolism and disposition of the oral direct thrombin inhibitor, dabigatran, in humans.  Drug Metab Dispos. 2008;  36 386-399
  • 2 Cohen A T, Tapson V F, Bergmann J F, Goldhaber S Z, Kakkar A K, Deslandes B, Huang W, Zayaruzny M, Emery L, Anderson Jr F A. Venous thromboembolism risk and prophylaxis in the acute hospital care setting (ENDORSE study): a multinational cross-sectional study.  Lancet. 2008;  371 387-394
  • 3 Connolly S J, Ezekowitz M D, Yusuf S, Eikelboom J, Oldgren J, Parekh A, Pogue J, Reilly P A, Themeles E, Varrone J, Wang S, Alings M, Xavier D, Zhu J, Diaz R, Lewis B S, Darius H, Diener H C, Joyner C D, Wallentin L. Dabigatran versus warfarin in patients with atrial fibrillation.  N Engl J Med. 2009;  361 1139-1151
  • 4 Di Nisio M, Middeldorp S, Buller H R. Direct thrombin inhibitors.  N Engl J Med. 2005;  353 1028-1040
  • 5 Eriksson B I, Dahl O E, Rosencher N, Kurth A A, van Dijk C N, Frostick S P, Kalebo P, Christiansen A V, Hantel S, Hettiarachchi R, Schnee J, Buller H R. Oral dabigatran etexilate vs. subcutaneous enoxaparin for the prevention of venous thromboembolism after total knee replacement: the RE-MODEL randomized trial.  J Thromb Haemost. 2007;  5 2178-2185
  • 6 Eriksson B I, Dahl O E, Rosencher N, Kurth A A, van Dijk C N, Frostick S P, Prins M H, Hettiarachchi R, Hantel S, Schnee J, Buller H R. Dabigatran etexilate versus enoxaparin for prevention of venous thromboembolism after total hip replacement: a randomised, double-blind, non-inferiority trial.  Lancet. 2007;  370 949-956
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  • 9 Kubitza D, Haas S. Novel factor Xa inhibitors for prevention and treatment of thromboembolic diseases.  Expert Opin Investig Drugs. 2006;  15 843-855
  • 10 Liesenfeld K H, Schafer H G, Troconiz I F, Tillmann C, Eriksson B I, Stangier J. Effects of the direct thrombin inhibitor dabigatran on ex vivo coagulation time in orthopaedic surgery patients: a population model analysis.  Br J Clin Pharmacol. 2006;  62 527-537
  • 11 Stangier J, Eriksson B I, Dahl O E, Ahnfelt L, Nehmiz G, Stahle H, Rathgen K, Svard R. Pharmacokinetic profile of the oral direct thrombin inhibitor dabigatran etexilate in healthy volunteers and patients undergoing total hip replacement.  J Clin Pharmacol. 2005;  45 555-563
  • 12 Stangier J, Rathgen K, Stahle H, Gansser D, Roth W. The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects.  Br J Clin Pharmacol. 2007;  64 292-303

Dr. Natig Gassanov

Herzzentrum Köln, Klinik III für Innere Medizin

Kerpener Str. 62

50924 Köln

Phone: 0221/47832544

Email: Natig.Gassanov@uk-koeln.de

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