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Synfacts 2010(8): 0967-0967  
DOI: 10.1055/s-0030-1257796
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Oxidative Cyanation of Amines Using Heterogeneous Iron Phthalocyanines

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
S. Singhal, S. L. Jain*, B. Sain
Indian Institute of Petroleum, Dehradun, India
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Publication History

Publication Date:
22 July 2010 (online)

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Significance

Polymer-supported iron(II) phthalocyanines 1a and 1b were prepared by immobilization of FePcSO2Cl onto aminomethylated polystyrene resin and MeO-PEG 5000-NH2, respec-tively (eq. 1). The polymeric iron(II) phthalocyanines promoted oxidative cyanation of tertiary amines 2 with sodium cyanide and hydrogen peroxide gave the corresponding α-amino nitriles 3 in up to 92% yield (eq. 2, 10 examples).