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Synfacts 2010(9): 1052-1052  
DOI: 10.1055/s-0030-1257894
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Amide-Directed sp³ C-H Arylation

Contributor(s): Paul Knochel, Tobias Thaler
M. Wasa, J.-Q. Yu*
The Scripps Research Institute, La Jolla, USA
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Publication History

Publication Date:
23 August 2010 (online)

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Significance

The CONHC6F5 amide group was shown to efficiently direct Csp³-H arylation in both Pd(II)/Pd(IV) and Pd(0)/Pd(II) catalytic cycles. Thus, this opens a new efficient access to the C-H functionalization of aliphatic carboxylic acid derived substrates possessing α-hydrogen atoms.