Download PDF
Synfacts 2010(9): 0996-0996  
DOI: 10.1055/s-0030-1258007
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Silver- and Iron-Catalyzed Synthesis of Substituted Thiazoles

Contributor(s): Victor Snieckus, Johnathan Board
X. Gao, Y.-m. Pan, M. Lin, L. Chen, Z.-p. Zhan*
Xiamen University, P. R. of China
Further Information

Publication History

Publication Date:
23 August 2010 (online)

    Permissions and Reprints

Significance

Reported is the synthesis of substituted thiazoles through the silver(I) triflate catalyzed reaction of propargyl alcohols with thio­amides. Also reported is a one-pot synthesis of thiazoles through the iron(III) chloride catalyzed ­reaction of propargyl alcohols with amides followed by sulfurization effected by Lawesson’s ­reagent and then ring closure. Mechanisms for these reactions were proposed but no evidence was provided.