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Synthesis 2011(1): 91-96  
DOI: 10.1055/s-0030-1258321
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

CuSO4-Mediated Homocoupling of Arylboronic Acids under Ligand- and Base-Free Conditions in Air

Babak Kaboudin*a,b, Terumitsu Harukib, Tsutomu Yokomatsu*b
a Department of Chemistry, Institute for Advanced Studies in Basic Sciences (IASBS), Zanjan 45137-66731, Iran
Fax: +98(241)4214949; e-Mail: kaboudin@iasbs.ac.ir;
b School of Pharmacy, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horonouchi, Hachioji, Tokyo 192-0392, Japan
Fax: +81(42)676 3239; e-Mail: yokomatu@ps.toyaku.ac.jp;
Further Information

Publication History

Received 28 September 2010
Publication Date:
09 November 2010 (online)

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Abstract

The homocoupling of arylboronic acids mediated by very inexpensive and air stable copper(II) sulfate in N,N-dimethylformamide affords the corresponding symmetrical biaryls in moderate to good yields. The homocoupling reaction proceeds in air at 50 ˚C in the presence of molecular sieves without any additives such as base and ligand.

Key words

homocoupling - arylboronic acids - copper(II) sulfate - biaryls

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