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Synfacts 2011(3): 0343-0343  
DOI: 10.1055/s-0030-1259460
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Selective Synthesis of Secondary Amines with Cu(OH)x/Al2O3

Contributor(s): Yasuhiro Uozumi, Go Hamasaka
J. He, K. Yamaguchi, N. Mizuno*
The University of Tokyo, Japan
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Publication History

Publication Date:
16 February 2011 (online)

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Significance

Aluminum-supported copper hydroxide Cu(OH)x/Al2O3 catalyzed the N-alkylation of primary amines 1, urea, or NH3 with benzyl alcohols 2 in mesitylene to give the corresponding secondary amines in 70-98% GC yield (14 examples). The catalyst was recovered by simple filtration and reused without significant loss of activity for the formation of 3c (75 min, 75% GC yield).