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Synthesis 2011(10): 1532-1536  
DOI: 10.1055/s-0030-1260002
PAPER
© Georg Thieme Verlag Stuttgart ˙ New York

Enantioselective Synthesis of the Tetracyclic Core of Platensimycin

Yohei Ueda, Kayoko Iwahashi, Kazuo Iguchi, Hisanaka Ito*
School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, 1432-1 Horinouchi, Hachioji, Tokyo 192-0392, Japan
Fax: +81(42)6765473; e-Mail: itohisa@toyaku.ac.jp;
Further Information

Publication History

Received 4 March 2011
Publication Date:
15 April 2011 (online)

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Abstract

A concise preparative method for the tetracyclic core of platensimycin in an optically active form was developed through a nine-step sequence from p-anisaldehyde without the use of protecting groups.

Key words

antibiotics - enantioselective hydrogenation - iodoetherification - formal synthesis

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