Convenient One-Pot Synthesis
of Functionalized Thieno[3,2-d]pyrimidine
and Thieno[2,3-d]pyrimidine
Derivatives

Antonio Fernández-Mato; Carlos Peinador; José María Quintela

doi:10.1055/s-0030-1260217

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Synthesis 2011(20): 3323-3331
DOI: 10.1055/s-0030-1260217

PAPER

Convenient One-Pot Synthesis of Functionalized Thieno[3,2-d]pyrimidine and Thieno[2,3-d]pyrimidine Derivatives

Antonio Fernández-Mato, Carlos Peinador*, José María Quintela*
Departamento de Química Fundamental, Facultad de Ciencias, Universidade da Coruña, Campus A Zapateira, 15008, A Coruña, Spain
Fax: +34(981)167065; e-Mail: jose.maria.quintela@udc; e-Mail: carlos.peinador@udc;

Further Information

Publication History

Received 7 June 2011
Publication Date:
08 September 2011 (online)

Abstract
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Abstract

A versatile one-pot method was developed for the preparation of a range of functionalized thieno[3,2-d]pyrimidine and thieno[2,3-d]pyrimidine derivatives. This protocol significantly reduces the cost and time for the synthesis of these compounds in comparison with previous routes, while facilitating scale up to multigram quantities in good yields (66-99%). The technique also permits the synthesis of bis(thienopyrimidine) derivatives not readily available by other methods.

Key words

heterocycles - domino reaction - Wittig reaction - bicyclic compounds - cyclization

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