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Synfacts 2011(9): 0987-0987
DOI: 10.1055/s-0030-1260865
DOI: 10.1055/s-0030-1260865
Metal-Catalyzed Asymmetric Synthesis and Stereoselective Reactions
© Georg Thieme Verlag
Stuttgart ˙ New York
Asymmetric Mo-Catalyzed Allylic Alkylation of Cyano Esters
B. M. Trost*, J. R. Miller, C. M. Hoffman, Jr.
Stanford University, USA
Further Information
Publication History
Publication Date:
19 August 2011 (online)
Significance
The authors reported a highly stereoselective and regioselective molybdenum-catalyzed allylic alkylation of cyanoesters. Various highly functionalized branched cyanoesters bearing vicinal tertiary and quaternary stereogenic centers are obtained in excellent yield and chemoselectivity and in good to excellent diastereoselectivity and enantioselectivity.