Synthesis of Toll-like Receptor Agonist PF-4171455

G. Bish; P. B. Hodgson et al.

doi:10.1055/s-0030-1261040

Subscribe to RSS

Please copy the URL and add it into your RSS Feed Reader.

https://www.thieme-connect.de/rss/thieme/en/10.1055-s-00000131.xml

Share / Bookmark

Facebook X Linkedin Weibo

Download PDF

Synfacts 2011(10): 1046-1046
DOI: 10.1055/s-0030-1261040

Synthesis of Natural Products and Potential Drugs

Synthesis of Toll-like Receptor Agonist PF-4171455

Contributor(s): Philip Kocienski
G. Bish*, P. B. Hodgson et al.*
Pfizer Global Research and Development, Sandwich and London, UK

Further Information

Publication History

Publication Date:
20 September 2011 (online)

Permissions and Reprints

Significance

Toll-like receptor 7 (TLR7) recognizes single-stranded RNA from viral pathogens and helps mount a challenge to them. PF-4171455 is an agonist of TLR7 that is of interest for antiviral applications. An 11-step synthesis delivered 8.8 kg of the target molecule in 11% overall yield.