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Synfacts 2011(10): 1124-1124  
DOI: 10.1055/s-0030-1261082
Metal-Mediated Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Synthesis of Polyfluoro-2,2-diarylethanes

Contributor(s): Paul Knochel, Nadja M. Barl
G. K. S. Prakash*, F. Paknia, T. Mathew, G. Mlostoń, J. P. Joshek, G. A. Olah*
University of Southern California, Los Angeles, USA
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

Herein, the direct synthesis of 1,1,1-trifluoro- and 1,1-difluoro-2,2-diarylethanes via a superacidic BF3-H2O-catalyzed Friedel-Crafts hydroxylation is disclosed. Different arenes efficiently react with trifluoroacetaldehyde methyl hemiacetal and difluoroacetaldehyde ethyl hemiacetal, respectively.