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Synfacts 2011(10): 1139-1139  
DOI: 10.1055/s-0030-1261088
Polymer-Supported Synthesis
© Georg Thieme Verlag Stuttgart ˙ New York

Cross-Coupling Using Mesoporous Pd-MCM-48

Contributor(s): Yasuhiro Uozumi, Toshimasa Suzuka
S. Banerjee*, H. Khatri, V. Balasanthiran, R. T. Koodali*, G. Sereda*
The University of South Dakota, Vermillion, USA
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Publication History

Publication Date:
20 September 2011 (online)

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Significance

Pd-MCM-48 was found to promote the Sonogashira coupling reaction. The coupling of phenylacetylene (3a) with iodobenzene (4a) was carried out in the presence of mesoporous silica supported Pd nanoparticles, Pd-MCM-48 (2), to give diphenylacetylene (5a) in 85% yield. Various acetylenes and aryl halides underwent the Sonogashira coupling reaction under similar reaction conditions to give the corresponding products 5 in 65-90% yield.