Download PDF
Synfacts 2011(10): 1052-1052  
DOI: 10.1055/s-0030-1261101
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart ˙ New York

Pd-Catalyzed Synthesis of Quinazolin-4(3H)-ones from N-Aryl Amidines

Contributor(s): Victor Snieckus, Yigang Zhao
B. Ma, Y. Wang, J. Peng, Q. Zhu*
Guangzhou Institutes of Biomedicine and Health, P. R. of China
Further Information

Publication History

Publication Date:
20 September 2011 (online)

    Permissions and Reprints

Significance

Reported is a concise synthesis of quinazolin-4(3H)-ones, in which readily available N-aryl amidines in the presence of CO smoothly undergo a Pd-catalyzed intramolecular C-H activation-carboxamidation to afford the quinazolin­one products in moderate to good yields. Notably, 1 atm of CO is sufficient for this process. However, the reaction scope and limitations were not well investigated.