Neoclerodane Diterpenoids from Scutellaria barbata

Abstract

Eight new neoclerodane diterpenoids (1–8), scutebatas H–O, together with eight known compounds, have been isolated from the whole plant of Scutellaria barbata D. Don. Their structures were elucidated on the basis of spectroscopic studies. In vitro cytotoxicity of selected compounds against cancer cell lines HL-60, SMMC-7721, A-549, MCF-7, and SW480 was evaluated. Compounds 5, 6, 7 showed moderate cytotoxicities against several human cancer cell lines, with IC₅₀ values ranging from 12.6–31.4 µM. In addition, compound 1 showed selective cytotoxicity against MCF-7.

Supporting information available online at http://www.thieme-connect.de/ejournals/toc/plantamedica

Key words

Scutellaria barbata - Lamiaceae - neoclerodane diterpenoids - scutebatas H–O - cytotoxicity

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