Oleanane-Type Triterpene Saponins and Cassaine-Type Diterpenoids from Erythrophleum fordii

Abstract

Phytochemical investigation of the EtOH extract of the leaves of Erythrophleum fordii led to the isolation of two oleanane-type triterpene saponins (1–2) and five cassaine-type diterpenoids (4–8) along with one known methyl 3β-hydroxy-erythrosuamate (3). Their structures were established by extensive NMR, as well as ESI‐MS analyses and acid hydrolysis. Biological evaluation of compounds 3–8 against five human cancer cell lines revealed that compounds 5–7 exhibited potent cytotoxic activity with IC₅₀ values ranging from 1.51 to 8.68 µM.

Key words

Erythrophleum fordii Oliver - Leguminosae - oleanane‐type triterpene saponin - cassaine‐type diterpenoid - cytotoxic activity

References

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