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Int J Angiol 2008; 17(2): 63-70
DOI: 10.1055/s-0031-1278283
Review

© Georg Thieme Verlag KG Stuttgart · New York

Risk factors for progression of calcific aortic stenosis and potential therapeutic targets

Ashvin R Kamath, Ramdas G Pai
  • Loma Linda University Medical Center, Loma Linda, California, USA
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Publication History

Publication Date:
28 April 2011 (online)

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Abstract

Current thought regarding the progression of calcific aortic stenosis (AS) is presented. After summarizing contemporary ideas about AS pathogenesis, the present article examines the factors that may affect disease progression. Data indicate that this process may be accelerated by aortic valve structure, degree of valvular calcification, chronic renal insufficiency and cardiovascular risk factors such as diabetes and dyslipidemia. Finally, the present review discusses potential therapeutic targets to slow AS progression.

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