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Int J Angiol 2008; 17(4): 193-196
DOI: 10.1055/s-0031-1278308
Original Article

© Georg Thieme Verlag KG Stuttgart · New York

Nonarteritic anterior ischemic optic neuropathy treated with intravenous prostaglandin E1 and steroids

Robert D Steigerwalt1 , M Rosaria Cesarone2 , Gianni Belcaro2 , Antonella Pascarella3 , Mauro De  Angelis3 , Sabrina Bacci4
  • 1Via A Brofferio, Rome, Italy
  • 2Irvine Vascular Labs, San Valentino, Pescara
  • 3Ophthalmic Hospital, Rome, Italy
  • 4Via Andrea Millevoi, Rome, Italy
Further Information

Publication History

Publication Date:
28 April 2011 (online)

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Abstract

BACKGROUND: Acute nonarteritic anterior ischemic optic neuropathy (NAION) is considered to be acute ischemia of the posterior ciliary arteries. Prostaglandin E1 (PGE1), a powerful microcirculation vasodilator, has been shown to improve ocular blood flow.

DESIGN: A nonrandomized, comparative trial.

METHODS: Eight consecutive cases of NAION were treated with intravenous steroids and PGE1. Seven control cases of NAION were treated with acetylsalicylic acid and oral steroids. Fisher's exact test was used for statistical analysis.

RESULTS: The visual acuity improved in seven cases of NAION treated with PGE1 and was unchanged in one. Of the seven control cases, four had no change in vision and three lost further visual acuity on follow-up visits.

CONCLUSIONS: Intravenous PGE1 and steroids should be considered in cases of NAION to immediately restore blood flow to the optic nerve and improve visual acuity.

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