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Planta Med 2011; 77(18): 2029-2036
DOI: 10.1055/s-0031-1280024
Natural Product Chemistry
Original Papers
© Georg Thieme Verlag KG Stuttgart · New York

Tea Triterpenoidal Saponins from the Roots of Camellia sinensis Have Inhibitory Effects against Alcohol Dehydrogenase

Titto Varughese1 , Md. Maniruzzaman Manir1 , Mozahidur Rahaman1 , Jeong Kee Kim2 , Byeong-Gon Lee2 , Surk-Sik Moon1
  • 1Department of Chemistry, Kongju National University, Gongju, Republic of Korea
  • 2Skin Research Institute, AmorePacific R & D Center, Yongin, Republic of Korea
Further Information

Publication History

received October 31, 2010 revised May 14, 2011

accepted June 2, 2011

Publication Date:
22 July 2011 (online)

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Abstract

Ten new polyhydroxyolean-12-ene pentacyclic triterpenoidal saponins, named rogchaponins 1–10, were isolated from the methanolic extract of the roots of Camellia sinensis by a series of chromatographic methods (silica gel flash column and C18 MPLC followed by C18 HPLC). Their structures were established by 1D and 2D-NMR techniques along with IR and HR-TOF-MS. Rogchaponins R4 (4) and R5 (5) showed inhibitory activities against yeast alcohol dehydrogenase (ADH) with IC50 values of 16.1 ± 3.2 and 15.4 ± 3.3 µM, respectively. A 4-methylpyrazole positive control exhibited an IC50 of 2750 ± 50 µM. However, the saponins showed no inhibitory activity against yeast aldehyde dehydrogenase (ALDH).

Key words

tea root - Camellia sinensis - Theaceae - triterpenoid saponin - rogchaponin - alcohol dehydrogenase

Supporting Information

References

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Prof. Dr. Surk-Sik Moon

Department of Chemistry
Kongju National University

Gongju 314-701

Republic of Korea

Phone: +82 4 18 50 84 95

Fax: +82 4 18 50 84 79

Email: ssmoon@kongju.ac.kr

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