Molybdenum Hexacarbonyl Mediated
CO Gas-Free Carbonylative Reactions

Luke R. Odell; Francesco Russo; Mats Larhed

doi:10.1055/s-0031-1290350

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Synlett 2012(5): 685-698
DOI: 10.1055/s-0031-1290350

ACCOUNT

Molybdenum Hexacarbonyl Mediated CO Gas-Free Carbonylative Reactions

Luke R. Odell*, Francesco Russo, Mats Larhed*
Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, Box 574, SE-75123 Uppsala, Sweden
Fax: +46184714474; e-Mail: luke.odell@orgfarm.uu.se; e-Mail: mats.larhed@orgfarm.uu.se;

Further Information

Publication History

Received 31 August 2011
Publication Date:
10 February 2012 (online)

Abstract
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Abstract

This Account summarizes predominately our own experiences in developing microwave-heated palladium-catalyzed Mo(CO)₆-mediated gas-free carbonylative reactions, although contributions from other groups, including non-palladium-catalyzed examples, have also been covered. Presented reactions include amino-, amido-, and alkoxycarbonylations as well as carbonylative cyclizations and carbonylative cross-couplings, using Mo(CO)₆ as a solid source of CO. The methodology was developed mainly for rapid small-scale applications, avoiding the problematic use of gaseous CO in a standard laboratory. In most cases, the reported Mo(CO)₆-mediated carbonylations were conducted in sealed vessels and with reaction times of less than 1 hour. The Account also highlights relevant applications in medicinal and high-speed chemistry.

1 Introduction

2 Mo(CO)₆-PromotedCarbonylations - The Beginning

3 Aminocarbonylations

4 Amidocarbonylations

5 Alkoxy- and Hydroxycarbonylations

6 Carbonylative Ring Closing of Aryl Halides

7 Carbonylative Cross-Couplings

8 Palladium-Free Mo(CO)₆-Promoted Carbonylations

9 Summary and Outlook

Key words

carbonylation - molybdenum - multicomponent reaction - palladium - catalysis

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3

For a more detailed discussion on the reaction mechanism, see references 2c-f and the articles cited therein.