A Novel Multicomponent Tandem Phosphine-Catalyzed Umpolung Reaction: Facile Access to Highly Functionalized α-Aminonitriles

Abstract

The first phosphine-catalyzed multicomponent tandem Strecker–γ-umpolung-addition reaction has been developed, which provides a facile access to functionalized allylic α-aminonitriles. The reaction is highly efficient, rapid, versatile and economical, and it is hoped that it will find great practical application in organic synthesis.

Key words

Strecker reaction - umpolung addition - α-aminonitrile - allene - phosphine catalysis

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