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Synthesis 2012; 44(12): 1833-1840
DOI: 10.1055/s-0031-1291144
DOI: 10.1055/s-0031-1291144
special topic
Mechanistic Investigation of the Domino Oxy-Cope/Ene/Claisen Reaction and Its Application to the Synthesis of Desdimethyl Ambliol B
Further Information
Publication History
Received: 20 March 2012
Accepted: 22 March 2012
Publication Date:
01 June 2012 (online)
Abstract
We report an efficient and highly diastereoselective oxy-Cope/ene/Claisen reaction for the synthesis of decalin frameworks possessing four contiguous stereogenic centers. A detailed mechanistic investigation and its application to a short and protecting group free synthesis of desdimethyl ambliol B are presented.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synthesis.
- Supporting Information
-
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