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Arzneimittelforschung 1999; 49(2): 144-148
DOI: 10.1055/s-0031-1300375
Antibacterials · Antibiotics · Chemotherapeutics · Cytostatics
Editio Cantor Verlag Aulendorf (Germany)

Synthesis and Antileishmanial Activity of α-Cyano Ethyl Propenoates - a New Class of Antileishmanials

Suman Tiwari
a   Divisions of Parasitology Central Drug Research Institute, Lucknow, India
,
Suman Gupta
a   Divisions of Parasitology Central Drug Research Institute, Lucknow, India
,
Rama P. Tripathi
b   Medicinal Chemistry Central Drug Research Institute, Lucknow, India
,
Abdul R. Khan
b   Medicinal Chemistry Central Drug Research Institute, Lucknow, India
,
Jagdish Chandra Katiyar
a   Divisions of Parasitology Central Drug Research Institute, Lucknow, India
,
Amiya P. Bhaduri
b   Medicinal Chemistry Central Drug Research Institute, Lucknow, India
› Author Affiliations
Further Information

Publication History

Publication Date:
28 December 2011 (online)

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Summary

A number of ethyl propenoates were synthesised by condensation of appropriate aldehydes with ethyl cyanoacetate in basic medium. These compounds have been studied for their antileishmanial activities in vivo in hamsters. Two compounds exhibited 70-77% activities both by intramuscular and oral routes.

Zusammenfassung

Synthese und Anti-Leishmania-Aktivität von — einer neuen Klasse von Leishmania-hemmenden Substanzen

Eine Anzahl Ethyl-propionate wurde durch Kondensation geeigneter Aldehyde mit Ethyl-cyanoacetat in basischem Medium synthetisiert. Die Verbindungen wurden auf Anti-Leishmania-Aktivitat in vivo an Hamstern untersucht. Zwei Verbindungen zeigten 70- bis 77%ige Aktivität sowohl nach intramuskularer als auch bei oraler Applikation.

Key words

Antiparasitic agents - a-Cyano ethyl propenoates, antileishmanial activity, synthesis - Leishmania donovani