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Arzneimittelforschung 1999; 49(6): 538-540
DOI: 10.1055/s-0031-1300457
Originalarbeit
Editio Cantor Verlag Aulendorf (Germany)

Antibacterial and Antifungal Activities of Complexes of Ruthenium (II)

Bekir Cetinkaya
a   Department of Chemistry, Ege University, Izmir, Turkey
,
Ismail Özdemir
b   Department of Chemistry, Inönü University, Malatya, Turkey
,
Beyhan Binbaştoğlu
b   Department of Chemistry, Inönü University, Malatya, Turkey
,
Selami Günal
c   Department of Clinical Microbiology, Faculty of Medicine Inönü University, Malatya, Turkey
› Author Affiliations
Further Information

Publication History

Publication Date:
28 December 2011 (online)

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Summary

Twenty ruthenium (II) complexes (1-5) were evaluated for their in vitro antibacterial and antifungal activity against Enterococcus faecalis (ATCC 29212) Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans and Candida tropicalis. Compounds 1d, 1e, 1h, 1i and 1j showed more pronounced antimicrobial activity against Gram-positive bacteria and fungi as compared to the nitrogen donor ruthenium complexes; hydrophobic substituents were significantly more effective. None of the compounds 1-5 exhibited antimicrobial activity against the Gram-negative strains Escherichia coli (ATCC 25922) and Pseudomonas aeruginosa (ATCC 27853) with the concentrations ranging between 12.5 and 800 μg/ml.

Zusammenfassung

Antibakterielle und antimykotische Wirkung von Ruthenium (II) - Komplexen

Zwanzig Ruthenium(H) Komplexe (1-5) wurden auf antibakterielle und antimykotische Wirkung gegen Enterococcus faecalis (ATCC 29212), Staphylococcus aureus (ATCC 29213), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Candida albicans und Candida tropicalis untersucht. Die Komplexe 1d, 1e, 1h, 1i und 1j zeigten eine stärkere antimikrobielle Wirkung gegen Gram-positive Bakterien und Pilze als die Stickstoff-Donor-Ruthenium-Komplexe; hydrophobe Substituenten waren signifikant wirksamer. Keine der Verbindungen 1-5 zeigten antimikrobielle Wirkung gegen die Gram-negativen Stämme Escherichia coli (ATCC 25922) und Pseudomonas aeruginosa (ATCC 27853) in einer Konzentration von 12,5 und 800 mg/ml.

Key words

Benzimidazole - Carbene complexes - Imidazoline - Ruthenium(H) complexes, antibacterial activity, antifungal activity, in vitro studies - Tetrahydropyridine - Vinylpyridine