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Neuropediatrics 2012; 43(03): 155-158
DOI: 10.1055/s-0032-1315430
Short Communication
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Medulloblastoma in a Child with Fragile X Syndrome

George A. Alexiou
1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece
,
George Siozos
2   Department of Pathology, Children's Hospital “Agia Sofia,” Athens, Greece
,
Kalliopi Stefanaki
2   Department of Pathology, Children's Hospital “Agia Sofia,” Athens, Greece
,
Eustathios Vlachakis
1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece
,
George Sfakianos
1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece
,
Neofytos Prodromou
1   Department of Neurosurgery, Children's Hospital “Agia Sofia,” Athens, Greece
,
Maria Moschovi
3   Department of Hematology Oncology, Unit of 1st Department of Pediatrics of Athens University, Children's Hospital “Agia Sofia,” Athens, Greece
› Author Affiliations
Further Information

Publication History

13 June 2011

30 April 2012

Publication Date:
17 May 2012 (online)

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Abstract

Fragile X syndrome is the most common cause of inherited intellectual impairment and has been associated with decreased incidence of cancer. We present the case of an 11-year-old boy with a diagnosis of fragile X syndrome who presented with gait imbalance, headache, and episodes of vomiting. Radiological investigation revealed the presence of a posterior fossa tumor. The patient was operated upon and the tumor proved to be a medulloblastoma (MB). To the best of our knowledge this is the first reported case of MB in a child with fragile X syndrome.

Keywords

medulloblastoma - fragile X syndrome - children
 

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