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Synlett 2013; 24(4): 496-498
DOI: 10.1055/s-0032-1318135
DOI: 10.1055/s-0032-1318135
letter
Simple Oxazolidine Chiral Diene Ligands for Enantioselective Rh-Catalyzed Conjugate Additions
Further Information
Publication History
Received: 12 December 2012
Accepted after revision: 08 January 2013
Publication Date:
23 January 2013 (online)
Abstract
Simple oxazolidine-based chiral diene ligands, ultimately derived from serine, have been synthesized using the Seebach self-regeneration of stereocenters strategy. The ligands have been used in the enantioselective Rh-catalyzed conjugate addition of aryl boronic acids to cyclohexenone. An efficient ‘in vacuo’ reaction protocol has been developed as part of this study.
Supporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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References and Notes
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For relevant reviews of chiral dienes and seminal reports of enantioselective Rh-catalyzed conjugate addition of boronic acids, see: