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Endoscopy 2013; 45(04): 320-323
DOI: 10.1055/s-0032-1326078
Case report/series
© Georg Thieme Verlag KG Stuttgart · New York

Outcome of screening endoscopy in common variable immunodeficiency disorder and X-linked agammaglobulinemia

L. J. Maarschalk-Ellerbroek
1   Department of Internal Medicine and Infectious Diseases, University Medical Centre of Utrecht, The Netherlands
,
B. Oldenburg
2   Department of Gastroenterology, University Medical Centre of Utrecht, The Netherlands
,
I. M. H. Mombers
1   Department of Internal Medicine and Infectious Diseases, University Medical Centre of Utrecht, The Netherlands
,
A. I. M. Hoepelman
1   Department of Internal Medicine and Infectious Diseases, University Medical Centre of Utrecht, The Netherlands
,
L. A. A. Brosens
3   Department of Pathology, University Medical Centre Utrecht, The Netherlands
,
G. J. A. Offerhaus
3   Department of Pathology, University Medical Centre Utrecht, The Netherlands
,
P. M. Ellerbroek
1   Department of Internal Medicine and Infectious Diseases, University Medical Centre of Utrecht, The Netherlands
› Author Affiliations
Further Information

Publication History

submitted 04 June 2012

accepted after revision 13 November 2012

Publication Date:
16 January 2013 (online)

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Gastrointestinal symptoms are common in patients with common variable immunodeficiency disorders (CVID) and less frequent in X-linked agammaglobulinemia (XLA) although the exact prevalence is not well established. In this study, endoscopic screening was performed in 30 patients with CVID and four patients with XLA. Endoscopic and/or histological abnormalities were detected in 25 of 30 patients with CVID (83 %), regardless of symptoms, and in nine of these patients the results prompted medical treatment. Helicobacter pylori-associated gastritis, adenomatous polyps, and lymphoid hyperplasia were most frequently encountered; no malignancies were detected. Adenomatous polyps were found in two of the four patients with XLA at a relative young age. In conclusion, gastrointestinal pathology is frequent in patients with CVID regardless of symptoms. Patients with XLA seem to be at risk for colorectal adenomas at a young age.

 

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