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Am J Perinatol 2013; 30(06): 451-462
DOI: 10.1055/s-0032-1326990
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Environmental Risk Factors and Perinatal Outcomes in Preterm Newborns, According to Family Recurrence of Prematurity

Hugo B. Krupitzki
1   Dirección de Investigación, CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Buenos Aires, Argentina
,
Enrique C. Gadow
1   Dirección de Investigación, CEMIC (Centro de Educación Médica e Investigaciones Clínicas), Buenos Aires, Argentina
,
Juan A. Gili
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
,
Belén Comas
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
,
Viviana R. Cosentino
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
,
César Saleme
3   Maternidad Nuestra Señora de la Merced, Tucumán, Argentina
,
Jeffrey C. Murray
4   Department of Pediatrics, University of Iowa, Iowa
,
Jorge S. Lopez Camelo
2   ECLAMC (Estudio Colaborativo Latinoamericano de Malformaciones Congénitas) at CEMIC, Buenos Aires, Argentina
5   IMBICE (Instituto Multidisciplinario de Biologia Celular), La Plata, Buenos Aires, Argentina
6   INAGEMP (Instituto Nacional de Genética Médica Populacional) at Laboratório de Epidemiologia de Malformações Congênitas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil
› Author Affiliations
Further Information

Publication History

07 March 2012

14 June 2012

Publication Date:
06 November 2012 (online)

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Abstract

Objective We analyzed the role of environmental risk factors, sociodemographic characteristics, clinical characteristics, and reproductive history in preterm births and their associated perinatal outcomes in families classified according to their histories of preterm recurrence among siblings.

Study Design A retrospective study was conducted at Nuestra Señora de la Merced Maternity Hospital in the city of Tucumán, Argentina. A total of 348 preterm, nonmalformed, singleton children born to multipara women were reviewed. The family history score described by Khoury was applied, and families were classified as having no, medium, or high genetic aggregation.

Results Families with no familial aggregation showed a higher rate of short length of cohabitation, maternal urinary tract infections during the current pregnancy, and maternal history of miscarriage during the previous pregnancy. Families with a high level of aggregation had a significantly higher incidence of pregnancy complications, such as diabetes, hypertension, and immunologic disorders.

Conclusion Reproductive histories clearly differed between the groups, suggesting both a different response to environmental challenges based on genetic susceptibility and the activation of different pathophysiological pathways to determine the duration of pregnancy in each woman.

Keywords

preterm birth - familial aggregation - pregnancy
 

  • References

  • 1 Muglia LJ, Katz M. The enigma of spontaneous preterm birth. N Engl J Med 2010; 362: 529-535
    Google Scholar
  • 2 Barth Jr WH. Familial spontaneous preterm birth: further evidence of a complex genetic disease. Obstet Gynecol 2010; 115: 1114-1115
    CrossrefPubMedGoogle Scholar
  • 3 Adams MM, Elam-Evans LD, Wilson HG, Gilbertz DA. Rates of and factors associated with recurrence of preterm delivery. JAMA 2000; 283: 1591-1596
    CrossrefPubMedGoogle Scholar
  • 4 Carlini L, Somigliana E, Rossi G, Veglia F, Busacca M, Vignali M. Risk factors for spontaneous preterm birth: a Northern Italian multicenter case-control study. Gynecol Obstet Invest 2002; 53: 174-180
    CrossrefPubMedGoogle Scholar
  • 5 Carr-Hill RA, Hall MH. The repetition of spontaneous preterm labour. Br J Obstet Gynaecol 1985; 92: 921-928
    PubMedGoogle Scholar
  • 6 Cnattingius S, Granath F, Petersson G, Harlow BL. The influence of gestational age and smoking habits on the risk of subsequent preterm deliveries. N Engl J Med 1999; 341: 943-948
    CrossrefPubMedGoogle Scholar
  • 7 Ekwo EE, Gosselink CA, Moawad A. Unfavorable outcome in penultimate pregnancy and premature rupture of membranes in successive pregnancy. Obstet Gynecol 1992; 80: 166-172
    PubMedGoogle Scholar
  • 8 Basso O, Olsen J, Christensen K. Study of environmental, social, and paternal factors in preterm delivery using sibs and half sibs. A population-based study in Denmark. J Epidemiol Community Health 1999; 53: 20-23
    CrossrefPubMedGoogle Scholar
  • 9 Hoffman HJ, Bakketeig LS. Risk factors associated with the occurrence of preterm birth. Clin Obstet Gynecol 1984; 27: 539-552
    CrossrefPubMedGoogle Scholar
  • 10 Ehn NL, Cooper ME, Orr K , et al. Evaluation of fetal and maternal genetic variation in the progesterone receptor gene for contributions to preterm birth. Pediatr Res 2007; 62: 630-635
    CrossrefPubMedGoogle Scholar
  • 11 Treloar SA, Macones GA, Mitchell LE, Martin NG. Genetic influences on premature parturition in an Australian twin sample. Twin Res 2000; 3: 80-82
    CrossrefPubMedGoogle Scholar
  • 12 Clausson B, Lichtenstein P, Cnattingius S. Genetic influence on birthweight and gestational length determined by studies in offspring of twins. BJOG 2000; 107: 375-381
    CrossrefPubMedGoogle Scholar
  • 13 Porter TF, Fraser AM, Hunter CY, Ward RH, Varner MW. The risk of preterm birth across generations. Obstet Gynecol 1997; 90: 63-67
    CrossrefPubMedGoogle Scholar
  • 14 Magnus P, Bakketeig LS, Skjaerven R. Correlations of birth weight and gestational age across generations. Ann Hum Biol 1993; 20: 231-238
    CrossrefPubMedGoogle Scholar
  • 15 Johnstone F, Inglis L. Familial trends in low birth weight. BMJ 1974; 3: 659-661
    CrossrefPubMedGoogle Scholar
  • 16 Wilcox MA, Newton CS, Johnson IR. Paternal influences on birthweight. Acta Obstet Gynecol Scand 1995; 74: 15-18
    CrossrefPubMedGoogle Scholar
  • 17 Klebanoff MA, Mednick BR, Schulsinger C, Secher NJ, Shiono PH. Father's effect on infant birth weight. Am J Obstet Gynecol 1998; 178: 1022-1026
    CrossrefPubMedGoogle Scholar
  • 18 Basso O, Olsen J, Christensen K. Low birthweight and prematurity in relation to paternal factors: a study of recurrence. Int J Epidemiol 1999; 28: 695-700
    CrossrefPubMedGoogle Scholar
  • 19 Klebanoff MA, Schulsinger C, Mednick BR, Secher NJ. Preterm and small-for-gestational-age birth across generations. Am J Obstet Gynecol 1997; 176: 521-526
    CrossrefPubMedGoogle Scholar
  • 20 Selling KE, Carstensen J, Finnström O, Sydsjö G. Intergenerational effects of preterm birth and reduced intrauterine growth: a population-based study of Swedish mother-offspring pairs. BJOG 2006; 113: 430-440
    CrossrefPubMedGoogle Scholar
  • 21 Wilcox AJ, Skjaerven R, Lie RT. Familial patterns of preterm delivery: maternal and fetal contributions. Am J Epidemiol 2008; 167: 474-479
    CrossrefPubMedGoogle Scholar
  • 22 Svensson AC, Sandin S, Cnattingius S , et al. Maternal effects for preterm birth: a genetic epidemiologic study of 630,000 families. Am J Epidemiol 2009; 170: 1365-1372
    CrossrefPubMedGoogle Scholar
  • 23 Boyd HA, Poulsen G, Wohlfahrt J, Murray JC, Feenstra B, Melbye M. Maternal contributions to preterm delivery. Am J Epidemiol 2009; 170: 1358-1364
    CrossrefPubMedGoogle Scholar
  • 24 Bhattacharya S, Raja EA, Mirazo ER , et al. Inherited predisposition to spontaneous preterm delivery. Obstet Gynecol 2010; 115: 1125-1133
    CrossrefPubMedGoogle Scholar
  • 25 Anum EA, Springel EH, Shriver MD, Strauss III JF. Genetic contributions to disparities in preterm birth. Pediatr Res 2009; 65: 1-9
    Google Scholar
  • 26 Tan H, Wen SW, Walker M, Demissie K. Parental race, birth weight, gestational age, and fetal growth among twin infants in the United States. Early Hum Dev 2004; 80: 153-160
    CrossrefPubMedGoogle Scholar
  • 27 Palomar L, DeFranco EA, Lee KA, Allsworth JE, Muglia LJ. Paternal race is a risk factor for preterm birth. Am J Obstet Gynecol 2007; 197: 152 , e1–e7
    PubMedGoogle Scholar
  • 28 Simhan HN, Krohn MA. Paternal race and preterm birth. Am J Obstet Gynecol 2008; 198: 644 , e1–e6
    PubMedGoogle Scholar
  • 29 Kistka ZA, Palomar L, Lee KA , et al. Racial disparity in the frequency of recurrence of preterm birth. Am J Obstet Gynecol 2007; 196: 131 , e1–e6
    PubMedGoogle Scholar
  • 30 Plunkett J, Muglia LJ. Genetic contributions to preterm birth: implications from epidemiological and genetic association studies. Ann Med 2008; 40: 167-195
    CrossrefPubMedGoogle Scholar
  • 31 Dolan SM, Hollegaard MV, Merialdi M , et al. Synopsis of preterm birth genetic association studies: the preterm birth genetics knowledge base (PTBGene). Public Health Genomics 2010; 13: 514-523
    CrossrefPubMedGoogle Scholar
  • 32 Romero R, Velez Edwards DR, Kusanovic JP , et al. Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes. Am J Obstet Gynecol 2010; 202: 431 , e1–e34
    PubMedGoogle Scholar
  • 33 Manuck TA, Major HD, Varner MW, Chettier R, Nelson L, Esplin MS. Progesterone receptor genotype, family history, and spontaneous preterm birth. Obstet Gynecol 2010; 115: 765-770
    CrossrefPubMedGoogle Scholar
  • 34 Plunkett J, Borecki I, Morgan T, Stamilio D, Muglia LJ. Population-based estimate of sibling risk for preterm birth, preterm premature rupture of membranes, placental abruption and pre-eclampsia. BMC Genet 2008; 9: 44
    PubMedGoogle Scholar
  • 35 Goldenberg RL, Culhane JF, Iams JD, Romero R. Epidemiology and causes of preterm birth. Lancet 2008; 371: 75-84
    CrossrefPubMedGoogle Scholar
  • 36 Lockwood CJ, Kuczynski E. Risk stratification and pathological mechanisms in preterm delivery. Paediatr Perinat Epidemiol 2001; 15 (Suppl. 02) 78-89
    CrossrefPubMedGoogle Scholar
  • 37 Mercer BM, Macpherson CA, Goldenberg RL , et al; NICHD Maternal-Fetal Medicine Units Network. Are women with recurrent spontaneous preterm births different from those without such history?. Am J Obstet Gynecol 2006; 194: 1176-1184 ; discussion 1184–1185
    CrossrefPubMedGoogle Scholar
  • 38 Mumtaz G, Nassar AH, Mahfoud Z , et al. Consanguinity: a risk factor for preterm birth at less than 33 weeks' gestation. Am J Epidemiol 2010; 172: 1424-1430
    CrossrefPubMedGoogle Scholar
  • 39 Nussbaum R, McInnes RR, Willard HF. Genetics of Common Disorders with Complex Inheritance. Thompson & Thompson Genetics in Medicine. Philadelphia: Saunders; 2007
    Google Scholar
  • 40 Ananth CV, Getahun D, Peltier MR, Salihu HM, Vintzileos AM. Recurrence of spontaneous versus medically indicated preterm birth. Am J Obstet Gynecol 2006; 195: 643-650
    CrossrefPubMedGoogle Scholar
  • 41 Savitz DA, Dole N, Herring AH , et al. Should spontaneous and medically indicated preterm births be separated for studying aetiology?. Paediatr Perinat Epidemiol 2005; 19: 97-105
    CrossrefPubMedGoogle Scholar
  • 42 Khoury MJ, Beaty TH, Cohen BH. Epidemiological approaches to familial aggregations. In: Press OU, , ed. Fundamentals of Genetics Epidemiology. New York: Oxford University Press, Inc.; 1993: 164-167
    Google Scholar
  • 43 Castilla EE, Orioli IM. ECLAMC: the Latin-American collaborative study of congenital malformations. Community Genet 2004; 7: 76-94
    CrossrefPubMedGoogle Scholar
  • 44 Manetti G, Rodas E, Morici P, Fernandez RG, Tonietto A, Oliveri N. Continuous quality improvement through use of perinatal clinical record and AGUSTINA database. Stud Health Technol Inform 1998; 52 (Pt 2) 824-826
    PubMedGoogle Scholar
  • 45 Pediatrics AAo. Obstetricians ACo, Gynecologists. Guidelines for Perinatal Care. Elk Grove Village, IL: American Academy of Pediatrics; 2002
    Google Scholar
  • 46 Dietz PM, England LJ, Callaghan WM, Pearl M, Wier ML, Kharrazi M. A comparison of LMP-based and ultrasound-based estimates of gestational age using linked California livebirth and prenatal screening records. Paediatr Perinat Epidemiol 2007; 21 (Suppl. 02) 62-71
    CrossrefPubMedGoogle Scholar
  • 47 Ananth CV, Vintzileos AM. Epidemiology of preterm birth and its clinical subtypes. J Matern Fetal Neonatal Med 2006; 19: 773-782
    CrossrefPubMedGoogle Scholar
  • 48 Savitz DA, Blackmore CA, Thorp JM. Epidemiologic characteristics of preterm delivery: etiologic heterogeneity. Am J Obstet Gynecol 1991; 164: 467-471
    CrossrefPubMedGoogle Scholar
  • 49 Moutquin JM. Classification and heterogeneity of preterm birth. BJOG 2003; 110 (Suppl. 20) 30-33
    CrossrefPubMedGoogle Scholar
  • 50 Pennell CE, Jacobsson B, Williams SM , et al; PREBIC Genetics Working Group. Genetic epidemiologic studies of preterm birth: guidelines for research. Am J Obstet Gynecol 2007; 196: 107-118
    CrossrefPubMedGoogle Scholar
  • 51 Khashan AS, McNamee R, Abel KM , et al. Rates of preterm birth following antenatal maternal exposure to severe life events: a population-based cohort study. Hum Reprod 2009; 24: 429-437
    CrossrefPubMedGoogle Scholar
  • 52 Risch N. Linkage strategies for genetically complex traits. I. Multilocus models. Am J Hum Genet 1990; 46: 222-228
    PubMedGoogle Scholar
  • 53 Huber PJ. Robust Statistics. New York: Wiley; 1981
    CrossrefGoogle Scholar
  • 54 Mazor-Dray E, Levy A, Schlaeffer F, Sheiner E. Maternal urinary tract infection: is it independently associated with adverse pregnancy outcome?. J Matern Fetal Neonatal Med 2009; 22: 124-128
    Google Scholar
  • 55 Sheiner E, Mazor-Drey E, Levy A. Asymptomatic bacteriuria during pregnancy. J Matern Fetal Neonatal Med 2009; 22: 423-427
    CrossrefPubMedGoogle Scholar
  • 56 Zeitlin JA, Saurel-Cubizolles MJ, Ancel PY. EUROPOP Group. Marital status, cohabitation, and risk of preterm birth in Europe: where births outside marriage are common and uncommon. Paediatr Perinat Epidemiol 2002; 16: 124-130
    CrossrefPubMedGoogle Scholar
  • 57 Remez L. Married mothers fare the best economically, even if they were unwed at the time they gave birth. Fam Plann Perspect 1999; 31: 258-259
    CrossrefPubMedGoogle Scholar
  • 58 Bracher M, Santow G. Economic independence and union formation in Sweden. Population Studies 1998; 52: 275-294
    CrossrefPubMedGoogle Scholar
  • 59 Hedegaard M, Henriksen TB, Sabroe S, Secher NJ. Psychological distress in pregnancy and preterm delivery. BMJ 1993; 307: 234-239
    CrossrefPubMedGoogle Scholar
  • 60 Gadow EC, Paz JE, López-Camelo JS , et al; NFP-ECLAMC Group. Latin American Collaborative Study of Congenital Malformations. Unintended pregnancies in women delivering at 18 South American hospitals. Hum Reprod 1998; 13: 1991-1995
    CrossrefPubMedGoogle Scholar
  • 61 Getahun D, Fassett MJ, Jacobsen SJ. Gestational diabetes: risk of recurrence in subsequent pregnancies. Am J Obstet Gynecol 2010; 203: 467 , e1–e6
    PubMedGoogle Scholar
  • 62 Wein P, Dong ZG, Beischer NA, Sheedy MT. Factors predictive of recurrent gestational diabetes diagnosed before 24 weeks' gestation. Am J Perinatol 1995; 12: 352-356
    Article in Thieme ConnectPubMedGoogle Scholar
  • 63 Ruiz-Irastorza G, Crowther M, Branch W, Khamashta MA. Antiphospholipid syndrome. Lancet 2010; 376: 1498-1509
    CrossrefPubMedGoogle Scholar
  • 64 Rasmussen S, Irgens LM. Occurrence of placental abruption in relatives. BJOG 2009; 116: 693-699
    CrossrefPubMedGoogle Scholar
  • 65 Rasmussen S, Albrechtsen S, Dalaker K. Obstetric history and the risk of placenta previa. Acta Obstet Gynecol Scand 2000; 79: 502-507
    CrossrefPubMedGoogle Scholar
  • 66 Monica G, Lilja C. Placenta previa, maternal smoking and recurrence risk. Acta Obstet Gynecol Scand 1995; 74: 341-345
    CrossrefPubMedGoogle Scholar
  • 67 Petersson K, Bremme K, Bottinga R , et al. Diagnostic evaluation of intrauterine fetal deaths in Stockholm 1998–99. Acta Obstet Gynecol Scand 2002; 81: 284-292
    CrossrefPubMedGoogle Scholar
  • 68 Van Regemorter N, Smith C. The importance of determining the mode of inheritance for the estimation of recurrence risks. J Genet Hum 1976; 24: 49-60
    PubMedGoogle Scholar
  • 69 Smith C. Recurrence risks for multifactorial inheritance. Am J Hum Genet 1971; 23: 578-588
    PubMedGoogle Scholar
  • 70 Yasui Y, Newcomb PA, Trentham-Dietz A, Egan KM. Familial relative risk estimates for use in epidemiologic analyses. Am J Epidemiol 2006; 164: 697-705
    CrossrefPubMedGoogle Scholar
  • 71 Yang Q, Khoury MJ, Rodriguez C, Calle EE, Tatham LM, Flanders WD. Family history score as a predictor of breast cancer mortality: prospective data from the Cancer Prevention Study II, United States, 1982–1991. Am J Epidemiol 1998; 147: 652-659
    CrossrefPubMedGoogle Scholar
  • 72 Barros FC, Victora CG, Barros AJ , et al. The challenge of reducing neonatal mortality in middle-income countries: findings from three Brazilian birth cohorts in 1982, 1993, and 2004. Lancet 2005; 365: 847-854
    CrossrefPubMedGoogle Scholar
  • 73 Cuzick JA. A Wilcoxon-type test for trend. Stat Med 1985; 4: 87-90
    CrossrefPubMedGoogle Scholar