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Planta Med 2013; 79(08): 701-706
DOI: 10.1055/s-0032-1328461
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Antibacterial Sesquiterpenoid Derivatives from Ferula ferulaeoides

Tao Liu
1   School of Pharmacy, Fudan University, Shanghai, China
,
Khadijo Osman
2   Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom
,
Glenn W. Kaatz
3   The John D. Dingell Department of Veteranʼs Affairs Medical Center and Department of Internal Medicine, Division of Infectious Diseases, School of Medicine, Wayne State University, Detroit, Michigan, USA
,
Simon Gibbons
2   Department of Pharmaceutical and Biological Chemistry, UCL School of Pharmacy, London, United Kingdom
,
Qing Mu
1   School of Pharmacy, Fudan University, Shanghai, China
› Author Affiliations
Further Information

Publication History

received 05 November 2012
revised 27 February 2013

accepted 14 March 2013

Publication Date:
13 May 2013 (online)

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Abstract

Three new sesquiterpenoid derivatives 1, 2, and 3 were isolated from Ferula ferulaeoides. To confirm the structure, compound 2 was also synthesized via a condensation reaction between compound 1 and 2,2-dimethoxypropane. The structures of these three compounds were elucidated by means of spectroscopic and chemical methods. Their antibacterial activity against drug-resistant Staphylococcus aureus strains were evaluated with MIC values in the range of 0.5–128 µg/mL. Compounds 1 and 3 were capable of inhibiting efflux of ethidium bromide using an in vitro assay. The cytotoxicity of the compounds was evaluated on cultured HEK293 cells, and none of them showed toxicity to HEK293 cells at a concentration of 125 µg/mL.

Key words

Ferula ferulaeoides - Apiaceae - sesquiterpenoid - efflux inhibition - drug-resistant Staphylococcus aureus

Supporting Information

 

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