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Planta Med 2013; 79(08): 673-679
DOI: 10.1055/s-0032-1328541
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Triterpenoid Saponins with Anti-Myocardial Ischemia Activity from the Whole Plants of Clematis tangutica

Wei Zhang
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, PR China
,
Min-Na Yao   *
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, PR China
,
Hai-Feng Tang
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, PR China
2   Institute of Materia Medica, School of Pharmacy, Fourth Military Medical University, Xiʼan, PR China
,
Xiang-Rong Tian
3   Research & Development Center of Biorational Pesticide, College of Plant Protection, Northwest A&F University, Yangling, PR China
,
Min-Chang Wang
4   Nuclear Magnetic Resonance Center, Xiʼan Modern Chemistry Research Institute, Xiʼan, PR China
,
Lan-Ju Ji
5   Qinghai Yi-Xin Pharmaceutical Co., Ltd., Xining, PR China
,
Miao-Miao Xi
1   Department of Pharmacy, Xijing Hospital, Fourth Military Medical University, Xiʼan, PR China
› Author Affiliations
Further Information

Publication History

received 21 August 2012
revised 01 March 2013

accepted 29 March 2013

Publication Date:
13 May 2013 (online)

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Abstract

Four new triterpenoid saponins named clematangosides A−D (1–4) along with six known saponins (5–10) were isolated from the whole plants of Clematis tangutica. Their structures were determined by extensive spectral analysis and chemical evidences. All saponins were evaluated for their protective effects in hypoxia-induced myocardial injury model. Compounds 2–4, 6, and 10 exhibited anti-myocardial ischemia activities with ED50 values in the range of 75.77–127.22 µM.

Key words

Clematis tangutica - Ranunculaceae - triterpenoid saponin - anti-myocardial ischemia

* Co-first author.


Supporting Information

 

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