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Planta Med 2013; 79(09): 788-791
DOI: 10.1055/s-0032-1328556
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Steroidal Glycosides from Reineckia carnea herba and Their Antitussive Activity

Na Han
1   Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Ling Li Chen
1   Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Yao Wang
1   Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Rui Xue
1   Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Li Bo Zou
2   School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, China
,
Fang Liu
1   Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
,
Jun Yin
1   Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China
› Author Affiliations
Further Information

Publication History

received 05 August 2012
revised 15 March 2013

accepted 29 March 2013

Publication Date:
13 May 2013 (online)

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Abstract

Two new steroidal glycosides, 1α,3α-dihydroxy-5β-pregn-16-en-20-one 3-O-α-L-rhamnopyranoside (1) and 1β,3β,27-trihydroxycholest-16-en-22-one 1,3-di-O-α-L-rhamnoside (2), along with seven known steroidal glycosides (3–9), were isolated from Reineckia carnea herba. Their structures were determined by detailed analysis of their 1D- and 2D-NMR and MS spectra. Compound 9 was isolated for the first time from the Reineckia genus. Except for 8, compounds 2, 3, 4, 5, 6, 7, and 9 displayed clear in vitro antitussive activity.

Key words

Reineckia carnea - Liliaceae - steroidal glycosides - antitussive

Supporting Information

 

  • References

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