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Planta Med 2013; 79(11): 978-986
DOI: 10.1055/s-0032-1328650
Natural Product Chemistry
Original Papers
Georg Thieme Verlag KG Stuttgart · New York

Antiproliferative Triterpenoid Saponins from the Stem of Psychotria sp.

Cui-Xian Zhang   *
1   School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China
,
Dong-Mei Zhang   *
2   Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Min-Feng Chen
2   Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
,
Shan-Yue Guan
3   Instrumental Analysis & Research Center, Sun Yat-Sen University, Guangzhou, P. R. China
,
Jun-Hua Yao
3   Instrumental Analysis & Research Center, Sun Yat-Sen University, Guangzhou, P. R. China
,
Xi-Xin He
1   School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China
,
Ling-Fang Lei
1   School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China
,
Ying Zhong
1   School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China
,
Zhi-Fang Wang
1   School of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou, P. R. China
,
Wen-Cai Ye
2   Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou, P. R. China
› Author Affiliations
Further Information

Publication History

received 27 November 2012
revised 20 April 2013

accepted 12 May 2013

Publication Date:
26 June 2013 (online)

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Abstract

Six new triterpenoid saponins, psychotrianosides A–F (1–6), and two known triterpenoid saponins, psychotrianoside G (7) and ardisianoside D (8), were isolated from Psychotria sp. Their structures were determined mainly by spectroscopic methods. The cytotoxic activities of 1–8 against five human cancer cell lines (MDA-MB-231, MCF-7, MCF-7/ADM, HepG2, and HepG2/ADM) are reported for the first time. Psychotrianoside C (3) showed the most potent antiproliferative activity among these saponins, and the IC50 value of 3 against MDA-MB-231 was 2.391 ± 0.161 µM. Compound 3 was also found to induce apoptosis.

Key words

Rubiaceae - Psychotria sp. - triterpenoid saponins - antiproliferative

* These authors contributed equally to this work.


Supporting Information

 

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