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Planta Med 2013; 79(12): 1063-1067
DOI: 10.1055/s-0032-1328719
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

New 23-Spirocholestane Derivatives from Ypsilandra thibetica

Bai-Bo Xie
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Chang-Xiang Chen
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Yong-Hui Guo
2   Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, P. R. China
,
Yu-Ye Li
3   Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P. R. China
,
Ya-Juan Liu
3   Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P. R. China
,
Wei Ni
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
,
Liu-Meng Yang
3   Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P. R. China
,
Ning-Bo Gong
2   Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, P. R. China
,
Yong-Tang Zheng
3   Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P. R. China
,
Rui-Rui Wang
3   Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, P. R. China
,
Yang Lü
2   Institute of Materia Medica, Chinese Academy of Medical Sciences, Beijing, P. R. China
,
Hai-Yang Liu
1   State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China
› Author Affiliations
Further Information

Publication History

received 23 January 2013
revised 10 May 2013

accepted 20 May 2013

Publication Date:
01 July 2013 (online)

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Abstract

Three new unusual 23-spirocholestane derivatives, ypsilanogenin (1), ypsilanogenin 3-O-β-D-glucopyranoside (2), and 4′-acetylypsilanogenin 3-O-β-D-glucopyranoside (3), were isolated from the whole plants of Ypsilandra thibetica. The structures of compounds 1–3 were deduced by spectroscopic and chemical methods, and the structure of 1 was further confirmed by a single-crystal diffraction analysis. All isolates were evaluated for their inhibitory activities against HIV-1.

Key words

Ypsilandra thibetica - Liliaceae - 23-spirocholestane glycosides - anti-HIV-1 activity

Supporting Information

 

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