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Am J Perinatol 2013; 30(10): 795-804
DOI: 10.1055/s-0032-1333406
Original Article
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Endothelial Nitric Oxide Synthase Gene Polymorphisms and Risk of Preeclampsia

Hui-Ping Qi
1   Department of Ophthalmology, the First Affiliated Hospital, Harbin Medical University, China
,
William D. Fraser
2   Department of Obstetrics and Gynecology, Saint-Justine Hospital, University of Montreal, Montreal, Canada
,
Zhong-Cheng Luo
2   Department of Obstetrics and Gynecology, Saint-Justine Hospital, University of Montreal, Montreal, Canada
,
Pierre Julien
3   Laboratory of Endocrinology and Genomics, CHUL Research Center (CHUQ), Laval University, Québec, Canada
,
Francois Audibert
2   Department of Obstetrics and Gynecology, Saint-Justine Hospital, University of Montreal, Montreal, Canada
,
Shu-Qin Wei
2   Department of Obstetrics and Gynecology, Saint-Justine Hospital, University of Montreal, Montreal, Canada
› Author Affiliations
Further Information

Publication History

09 August 2012

30 October 2012

Publication Date:
17 January 2013 (online)

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Abstract

Polymorphisms in endothelial nitric oxide synthase (eNOS) gene may affect the risk of preeclampsia. This systematic review aimed to provide an updated review of the literature to better understand the association between the eNOS gene polymorphisms and the risk of preeclampsia. We searched electronic databases of the human literature in PubMed, EMBASE, and the Cochrane Library up to July 2012. A meta-analysis was conducted on the association of eNOS G894T, T786C, and intron 4b/a polymorphisms with preeclampsia using (1) allele contrast, (2) recessive, (3) dominant, and (4) additive models. Thirty-three studies comprising 10,671 participants met the inclusion criteria. There was statistically significant association between the G894T variant and increased risk of preeclampsia (TT versus TG + GG: odds ratio 1.43, 95% confidence interval: 1.13 to 1.82). However, no significant risk of preeclampsia was observed either in the T786C or the intron 4b/a polymorphism. Homozygosity TT in eNOS G894T variant is significantly associated with an increased risk of preeclampsia.

Keywords

preeclampsia - endothelial nitric oxide synthase - polymorphism
 

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