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Neuropediatrics 2013; 44(05): 272-275
DOI: 10.1055/s-0033-1336018
Short Communication
Georg Thieme Verlag KG Stuttgart · New York

Plasma Exchange Is Effective in a 13-Year-Old Girl with Steroid-Resistant Bilateral Optic Neuritis

Isabel Michaelis
1   Department of Paediatric Neurology, University Children's Hospital, Tübingen, Germany
,
Benjamin Bender
2   Department of Diagnostic and Interventional Neuroradiology, University Hospital Tübingen, Germany
,
Ortraud Beringer
3   Department of Paediatric Nephrology, University Children's Hospital, Ulm, Germany
,
Arthur Melms
4   Department of Neurology, University Hospital, Tübingen, Germany
,
Ingeborg Krägeloh-Mann
1   Department of Paediatric Neurology, University Children's Hospital, Tübingen, Germany
,
Markus Wolff
1   Department of Paediatric Neurology, University Children's Hospital, Tübingen, Germany
› Author Affiliations
Further Information

Publication History

27 August 2012

03 January 2013

Publication Date:
06 March 2013 (online)

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Abstract

We describe a 13-year-old girl presenting with steroid-resistant bilateral optic neuritis. After plasma exchange (PE), the girl experienced full recovery of her visual acuity. During a 4-year follow-up no relapse occurred. As far as we know, this is the first report of PE treatment in optic neuritis in a child.

Keywords

optic neuritis - steroid-resistant - plasma exchange - children
 

  • References

  • 1 Alper G, Wang L. Demyelinating optic neuritis in children. J Child Neurol 2009; 24 (1) 45-48
    CrossrefPubMedGoogle Scholar
  • 2 Wilejto M, Shroff M, Buncic JR, Kennedy J, Goia C, Banwell B. The clinical features, MRI findings, and outcome of optic neuritis in children. Neurology 2006; 67 (2) 258-262
    CrossrefPubMedGoogle Scholar
  • 3 Llufriu S, Castillo J, Blanco Y , et al. Plasma exchange for acute attacks of CNS demyelination: Predictors of improvement at 6 months. Neurology 2009; 73 (12) 949-953
    CrossrefPubMedGoogle Scholar
  • 4 Ruprecht K, Klinker E, Dintelmann T, Rieckmann P, Gold R. Plasma exchange for severe optic neuritis: treatment of 10 patients. Neurology 2004; 63 (6) 1081-1083
    CrossrefPubMedGoogle Scholar
  • 5 Krupp LB, Banwell B, Tenembaum S. International Pediatric MS Study Group. Consensus definitions proposed for pediatric multiple sclerosis and related disorders. Neurol (Tokyo) 2007; 68: 7-12
    CrossrefPubMedGoogle Scholar
  • 6 Beck RW, Trobe JD, Moke PS , et al; Optic Neuritis Study Group. High- and low-risk profiles for the development of multiple sclerosis within 10 years after optic neuritis: experience of the optic neuritis treatment trial. Arch Ophthalmol 2003; 121 (7) 944-949
    CrossrefPubMedGoogle Scholar
  • 7 Brady KM, Brar AS, Lee AG, Coats DK, Paysse EA, Steinkuller PG. Optic neuritis in children: clinical features and visual outcome. J AAPOS 1999; 3 (2) 98-103
    PubMedGoogle Scholar
  • 8 Candler PM, Dale RC. Three cases of central nervous system complications associated with Mycoplasma pneumoniae. Pediatr Neurol 2004; 31 (2) 133-138
    CrossrefPubMedGoogle Scholar
  • 9 Pohl D, Waubant E, Banwell B , et al; International Pediatric MS Study Group. Treatment of pediatric multiple sclerosis and variants. Neurology 2007; 68 (16) (Suppl. 02) S54-S65
    CrossrefPubMedGoogle Scholar
  • 10 Sethi HS, Menon V, Sharma P, Khokhar S, Tandon R. Visual outcome after intravenous dexamethasone therapy for idiopathic optic neuritis in an Indian population: a clinical case series. Indian J Ophthalmol 2006; 54 (3) 177-183
    CrossrefPubMedGoogle Scholar
  • 11 Weinshenker BG, O'Brien PC, Petterson TM , et al. A randomized trial of plasma exchange in acute central nervous system inflammatory demyelinating disease. Ann Neurol 1999; 46 (6) 878-886
    CrossrefPubMedGoogle Scholar
  • 12 Takahashi I, Sawaishi Y, Takeda O, Enoki M, Takada G. Childhood multiple sclerosis treated with plasmapheresis. Pediatr Neurol 1997; 17 (1) 83-87
    CrossrefPubMedGoogle Scholar
  • 13 Balestri P, Grosso S, Acquaviva A, Bernini M. Plasmapheresis in a child affected by acute disseminated encephalomyelitis. Brain Dev 2000; 22 (2) 123-126
    CrossrefPubMedGoogle Scholar