Synthesis of 1,2-Dimetallic Compounds via Direct Insertion of Zinc Powder in the Presence of InCl₃: Synthesis of ortho-Bis-functionalized Aromatics

Abstract

A variety of functionalized 1,2-dizinc reagents can be prepared by an indium-catalyzed insertion of zinc powder into aromatic 1,2-dibromides or 1-bromo-2-triflates. These 1,2-dimetallics undergo Cu- or Pd-catalyzed acylations, allylations, or cross couplings.

Key words

zinc - 1,2-dimetallic - insertion - cross-coupling - indium(III) chloride

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