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Synlett 2014; 25(07): 935-938
DOI: 10.1055/s-0033-1340860
DOI: 10.1055/s-0033-1340860
letter
Microwave-Assisted Synthesis of 4-Substituted 2-Methylthiopyrimidines
Further Information
Publication History
Received: 06 January 2014
Accepted after revision: 04 February 2014
Publication Date:
24 March 2014 (online)
Abstract
Typically, SNAr reactions at 4-chloro-2-methylthiopyrimidine are carried out employing DMF and sodium hydride under inert gas as well as prolonged reaction times. Herein, we describe a mild and rapid microwave-assisted synthesis to achieve 4-substituted 2-methylthiopyrimidnes from the corresponding chlorine precursor. Moderate to excellent yields were obtained in a green chemistry fashion requiring only few minutes of reaction time.
Key words
green chemistry - pyrimidine - combinatorial chemistry - medicinal chemistry - nucleophilic aromatic substitutionSupporting Information
- for this article is available online at http://www.thieme-connect.com/ejournals/toc/synlett.
- Supporting Information
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