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Pneumologie 2013; 67(S 02): S100-S101
DOI: 10.1055/s-0033-1344748
Extended Abstract
© Georg Thieme Verlag KG Stuttgart · New York

Wirkung des sGC-Stimulators Riociguat auf das pulmonalvaskuläre und rechtsventrikuläre Remodeling bei schwerer pulmonal-arterieller Hypertonie

Effects of sGC-stimulator Riociguat on Pulmonary Vascular and Right Ventricular Remodeling in Severe Pulmonary Arterial Hypertension
B. Kojonazarov
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
M. Lang
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
X. Tian
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
A. Kalymbetov
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
N. Weißmann
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
F. Grimminger
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
A. Kretschmer
2   Bayer Healthcare AG, Wuppertal
,
J.-P. Stasch
2   Bayer Healthcare AG, Wuppertal
,
H.-A. Ghofrani
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
W. Seeger
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
,
R. T. Schermuly
1   Universities of Giessen and Marburg Lung Center, Excellence Cluster Cardio-Pulmonary System, Member of the German Center for Lung Research, Giessen
› Author Affiliations
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Publication History

Publication Date:
09 December 2013 (online)

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Hintergrund

Der NO-sGC-cGMP-Signaltransduktionsweg (NO = Stickstoffmonoxid; sGC = lösliche Guanylatcyclase; cGMP = zyklisches Guanosinmonophosphat) ist bei vielen Herzkreislauferkrankungen einschließlich der pulmonal-arteriellen Hypertonie (PAH) gestört. Bei Riociguat (BAY 63 – 2521) handelt es sich um einen sGC-Stimulator, der den cGMP-Spiegel sowohl in Synergie mit NO als auch unabhängig davon erhöht. Ziel dieser Studie war es, die Rolle der NO-sGC-cGMP-Signalgebung in einem Modell mit schwerer PAH zu untersuchen und die Wirkung der sGC-Stimulation durch Riociguat sowie der PDE5-Inhibition durch Sildenafil auf die pulmonale Hämodynamik und das vaskuläre Remodeling bei schwerer experimenteller PAH zu bewerten.