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Planta Med 2013; 79(15): 1470-1473
DOI: 10.1055/s-0033-1350801
Natural Product Chemistry
Letters
Georg Thieme Verlag KG Stuttgart · New York

Antioxidant Lignans from the Roots of Vladimiria muliensis

Jian-Jun Chen
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Peopleʼs Republic of China
,
Hong-Bo Wei
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Peopleʼs Republic of China
,
Yuan-Zhen Xu
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Peopleʼs Republic of China
,
Jun Zeng
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Peopleʼs Republic of China
,
Kun Gao
State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, Peopleʼs Republic of China
› Author Affiliations
Further Information

Publication History

received 15 January 2013
revised 18 July 2013

accepted 07 August 2013

Publication Date:
17 September 2013 (online)

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Abstract

Three new lignans (1, 2, and 8) and ten known ones (3–7, 9–13) were isolated from the roots of Vladimiria muliensis. Their structures and configurations were elucidated by means of spectroscopic techniques (IR, MS, NMR, and CD) and chemical methods. The isolated compounds were evaluated for their antioxidant and antibacterial activities. The antioxidant activity was the greatest for lignans 7 and 10 with IC50 values of 11.2 and 7.3 µM against DPPH radical, and of 1.6 and 1.7 µM against ABTS+ radical, respectively. Moreover, 7 also displayed broad-spectrum antibacterial activity with MIC values around 7.25 µg/mL.

Key words

Vladimiria muliensis - Compositae - lignans - antioxidant activity - antibacterial activity

Supporting Information

 

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