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Horm Metab Res 2014; 46(03): 224-231
DOI: 10.1055/s-0033-1353204
Endocrine Care
© Georg Thieme Verlag KG Stuttgart · New York

The Effects of Weight Loss on FABP4 and RBP4 in Obese Women with Metabolic Syndrome

K. B. Comerford
1   Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The University of California at Davis Medical Center, Sacramento, CA, USA
,
W. Buchan
2   Family and Consumer Sciences Department, California State University Sacramento, Sacramento, CA, USA
,
S. E. Karakas
1   Division of Endocrinology, Diabetes and Metabolism, Department of Internal Medicine, The University of California at Davis Medical Center, Sacramento, CA, USA
› Author Affiliations
Further Information

Publication History

received 14 December 2012

accepted 25 July 2013

Publication Date:
26 August 2013 (online)

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Abstract

Fat accumulation is associated with the release of many novel adipokines such as retinol-binding protein 4 and fatty acid-binding protein 4. These adipokines have been linked to insulin resistance, metabolic syndrome, type 2 diabetes and cardiovascular disease. Since weight loss is the first step for the treatment of metabolic syndrome, which increases the risks for both type 2 diabetes and cardiovascular disease, we have investigated the effects of weight loss on serum retinol-binding protein 4 and fatty acid-binding protein 4 in obese individuals with this syndrome. Twenty-nine obese female subjects with metabolic syndrome, aged 18–62 years completed a 2-month weight loss diet plan. Data were collected from dual-energy X-ray absorptiometry and indirect calorimetry. Blood was taken at baseline and at 2 months and assayed for adipokines, lipids, and insulin resistance parameters. The change in circulating fatty acid-binding protein 4 levels were inversely correlated with total weight loss (p<0.02) and lean mass loss (p<0.01), but not with fat mass loss. Retinol-binding protein 4 levels did not track with any measure of body composition. Changes in leptin levels were found to correlate with weight loss (p<0.02), fat loss (p<0.03), and lean mass loss (p<0.05). Fatty acid-binding protein 4 levels increased and retinol-binding protein 4 levels did not change during moderate weight loss in obese women with metabolic syndrome; however, several other risk factors for type 2 diabetes and cardiovascular disease did improve with weight loss.

Key words

weight loss - adipokines - insulin resistance
 

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