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Aktuelle Neurologie 2013; 40(10): 559-573
DOI: 10.1055/s-0033-1358691
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© Georg Thieme Verlag KG Stuttgart · New York

Management von intrakraniellen Aneurysmen und Subarachnoidalblutungen: Vorstellung der Leitlinien der europäischen Schlaganfallorganisation (ESO)

Management of Intracranial Aneurysms and Subarachnoid Haemorrhages: Presentation of the Guidelines of the European Stroke Organisation (ESO)
B. Ikenberg
1   Klinikum Höchst, Neurologie, Frankfurt
,
M. Forsting
2   Klinik für Radiologie, Universität Essen
,
C. S. Jung
3   Neurochirurgische Klinik Universität Heidelberg
,
A. Unterberg
3   Neurochirurgische Klinik Universität Heidelberg
,
H. Steinmetz
4   Klinik für Neurologie, Johann Wolfgang Goethe-Universität Frankfurt
,
T. Steiner
1   Klinikum Höchst, Neurologie, Frankfurt
5   Neurologische Klinik, Universitätsklinikum Heidelberg
› Author Affiliations
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Publication History

Publication Date:
10 December 2013 (online)

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Zusammenfassung

Die europäische Schlaganfallgesellschaft (ESO) hat in diesem Jahr eine Leitlinie zur Behandlung der SAB (mit und ohne Nachweis von Aneurysmen) und von unrupturierten Aneurysmata (UIA) veröffentlicht. Wir stellen hier die Inhalte dieser Leitlinie im Sinne einer Übersetzung auf Deutsch vor. Wenige Passagen wurden gekürzt. Wichtige Publikationen, die in der Originalarbeit nicht berücksichtigt werden konnten, wurden unter entsprechender Kenntlichmachung (#) ergänzt. ­Subarachnoidalblutungen (SAB) stellen ein relevantes Gesundheitsproblem dar: weltweit wird die Inzidenz von SABs mit etwa 9/100000 angegeben, wobei deutliche regionalspezifische Unterschiede bestehen, mit Inzidenzen von bis zu 20/100000 in einigen Ländern. Die Mortalitätsraten konservativ behandelter Patienten liegen bei etwa 50–60% innerhalb von 30 Tagen. Ohne die Versorgung eines rupturierten Aneurysmas stirbt etwa ein Drittel der Patienten an einer Rezidivblutung innerhalb von 6 Monaten. Die Prognose wird vom Auftreten zerebraler Vasospasmen, eines Hydrozephalus, eines verzögerten ischämischen Defizits und weiteren Komplikationen beeinflusst.

Abstract

This year the European Stroke Organisation (ESO) published guidelines for the treatment of SAH (with and without associated aneurysms) and for unruptured intracranial aneurysms (UIA). Here we present these European guidelines as a translation into German. A few paragraphs were shortened. The data was supplemented by recent publications which had not been considered in the original article. Additional references are marked by (#). Subarachnoid haemorrhages (SAH) are of particular medical importance. The overall incidence of SAH is 9/100000, with a broad regionally specific range with up to 20/100000 cases per year in some countries. Patients who are treated conservatively have mortality rates up to 50–60% after 30 days. Approximately a third of patients with an untreated ruptured aneurysm die during the following 6 months due to a rebleeding. Furthermore, the prognosis is influenced by medical complications, such as cerebral vasospasms, hydrocephalus and delayed ischaemic deficits.

Schlüsselwörter

Subarachnoidalblutung - intrakranielles Aneurysma - perimesenzephale Subarachnoidalblutung - Management - Leitlinie

Keywords

subarachnoid haemorrhage - intracranial aneurysm - perimesencephalic subarachnoid haemorrhage - management - guidelines

Comment to this article:

Management von intrakraniellen Aneurysmen und Subarachnoidalblutungen: Vorstellung der Leitlinien der europäischen Schlaganfallorganisation (ESO)Aktuelle Neurologie 2014; 41(03): 179
DOI: 10.1055/s-0034-1369869

Comment to this article:

AntwortAktuelle Neurologie 2014; 41(03): 179-180
DOI: 10.1055/s-0034-1369870

 

  • Literatur

  • 1 van Gijn J, Kerr RS, Rinkel GJ. Subarachnoid haemorrhage. Lancet 2007; 369: 306-318
    CrossrefPubMedGoogle Scholar
  • #2 Johnston SC, Selvin S, Gress DR. The burden, trends, and demographics of mortality from subarachnoid hemorrhage. Neurology 1998; 50: 1413-1418
    CrossrefPubMedGoogle Scholar
  • #3 van Gijn J, Rinkel GJ. Subarachnoid haemorrhage: diagnosis, causes and management. Brain 2001; 124: 249-278
    CrossrefPubMedGoogle Scholar
  • 4 Connolly Jr ES, Rabinstein AA, Carhuapoma JR et al. Guidelines for the management of aneurysmal subarachnoid hemorrhage: a guideline for healthcare professionals from the American Heart Association/American Stroke Association. Stroke 2012; 43: 1711-1737
    CrossrefPubMedGoogle Scholar
  • #5 Diener HC, Berlit P, Deuschl G et al. Leitlinien für Diagnostik und Therapie in der Neurologie. Stuttgart: Georg Thieme Verlag; 2012
    Article in Thieme ConnectGoogle Scholar
  • #6 Steiner T, Juvela S, Unterberg A et al. European stroke organization guidelines for the management of intracranial aneurysms and subarachnoid haemorrhage. Cerebrovasc Dis 2013; 35: 93-112
    CrossrefPubMedGoogle Scholar
  • 7 Brainin M, Barnes M, Baron JC et al. Guidance for the preparation of neurological management guidelines by EFNS scientific task forces-revised recommendations 2004. Eur J Neurol 2004; 11: 577-581
    CrossrefPubMedGoogle Scholar
  • 8 Hunt WE, Hess RM. Surgical risk as related to time of intervention in the repair of intracranial aneurysms. J Neurosurg 1968; 28: 14-20
    CrossrefPubMedGoogle Scholar
  • 9 World Federation of Neurological Surgeons Committee . Report of World Federation of Neurological Surgeons Committee on a Universal Subarachnoid Hemorrhage Grading Scale. J Neurosurg 1988; 68: 985-986
    PubMedGoogle Scholar
  • 10 Takagi K, Tamura A, Nakagomi T et al. How should a subarachnoid hemorrhage grading scale be determined? A combinatorial approach based solely on the Glasgow Coma Scale. J Neurosurg 1999; 90: 680-687
    CrossrefPubMedGoogle Scholar
  • #11 Degen LA, Dorhout Mees SM, Algra A et al. Interobserver variability of grading scales for aneurysmal subarachnoid hemorrhage. Stroke 2011; 42: 1546-1549
    CrossrefPubMedGoogle Scholar
  • 12 van Heuven AW, Dorhout Mees SM, Algra A et al. Validation of a prognostic subarachnoid hemorrhage grading scale derived directly from the Glasgow Coma Scale. Stroke 2008; 39: 1347-1348
    CrossrefPubMedGoogle Scholar
  • 13 de Rooij NK, Linn FH, van der Plas JA et al. Incidence of subarachnoid haemorrhage: a systematic review with emphasis on region, age, gender and time trends. J Neurol Neurosurg Psychiatry 2007; 78: 1365-1372
    CrossrefPubMedGoogle Scholar
  • 14 Rinkel GJ, Djibuti M, Algra A et al. Prevalence and risk of rupture of intracranial aneurysms: a systematic review. Stroke 1998; 29: 251-256
    CrossrefPubMedGoogle Scholar
  • 15 Pakarinen S. Incidence, aetiology, and prognosis of primary subarachnoid haemorrhage. A study based on 589 cases diagnosed in a defined urban population during a defined period. Acta Neurol Scand 1967; 43 (Suppl. 29) 21-28
    CrossrefPubMedGoogle Scholar
  • 16 Huang J, van Gelder JM. The probability of sudden death from rupture of intracranial aneurysms: a meta-analysis. Neurosurgery 2002; 51: 1101-1105 discussion, 1105–1107
    CrossrefPubMedGoogle Scholar
  • #17 Rosenorn J, Eskesen V, Schmidt K et al. The risk of rebleeding from ruptured intracranial aneurysms. J Neurosurg 1987; 67: 329-332
    CrossrefPubMedGoogle Scholar
  • 18 Jane JA, Kassell NF, Torner JC et al. The natural history of aneurysms and arteriovenous malformations. J Neurosurg 1985; 62: 321-323
    CrossrefPubMedGoogle Scholar
  • 19 Nishioka H, Torner JC, Graf CJ et al. Cooperative study of intracranial aneurysms and subarachnoid hemorrhage: a long-term prognostic study. II. Ruptured intracranial aneurysms managed conservatively. Arch Neurol 1984; 41: 1142-1146
    CrossrefPubMedGoogle Scholar
  • 20 Nieuwkamp DJ, Setz LE, Algra A et al. Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis. Lancet Neurol 2009; 8: 635-642
    CrossrefPubMedGoogle Scholar
  • 21 Hop JW, Rinkel GJ, Algra A et al. Case-fatality rates and functional outcome after subarachnoid hemorrhage: a systematic review. Stroke 1997; 28: 660-664
    CrossrefPubMedGoogle Scholar
  • #22 Stegmayr B, Eriksson M, Asplund K. Declining mortality from subarachnoid hemorrhage: changes in incidence and case fatality from 1985 through 2000. Stroke 2004; 35: 2059-2063
    CrossrefPubMedGoogle Scholar
  • 23 Meyer B, Ringel F, Winter Y et al. Health-related quality of life in patients with subarachnoid haemorrhage. Cerebrovasc Dis 2010; 30: 423-431
    CrossrefPubMedGoogle Scholar
  • #24 Al-Khindi T, Macdonald RL, Schweizer TA. Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. Stroke 2010; 41: e519-e536
    CrossrefPubMedGoogle Scholar
  • 25 Juvela S. Prehemorrhage risk factors for fatal intracranial aneurysm rupture. Stroke 2003; 34: 1852-1857
    CrossrefPubMedGoogle Scholar
  • 26 Koffijberg H, Buskens E, Granath F et al. Subarachnoid haemorrhage in Sweden 1987–2002: regional incidence and case fatality rates. J Neurol Neurosurg Psychiatry 2008; 79: 294-299
    CrossrefPubMedGoogle Scholar
  • 27 Kassell NF, Torner JC, Haley Jr EC et al. The International Cooperative Study on the Timing of Aneurysm Surgery. Part 1: Overall management results. J Neurosurg 1990; 73: 18-36
    CrossrefPubMedGoogle Scholar
  • 28 Juvela S. Alcohol consumption as a risk factor for poor outcome after aneurysmal subarachnoid haemorrhage. BMJ 1992; 304: 1663-1667
    CrossrefPubMedGoogle Scholar
  • 29 Weir BK, Kongable GL, Kassell NF et al. Cigarette smoking as a cause of aneurysmal subarachnoid hemorrhage and risk for vasospasm: a report of the Cooperative Aneurysm Study. J Neurosurg 1998; 89: 405-411
    CrossrefPubMedGoogle Scholar
  • 30 Juvela S, Siironen J, Kuhmonen J. Hyperglycemia, excess weight, and history of hypertension as risk factors for poor outcome and cerebral infarction after aneurysmal subarachnoid hemorrhage. J Neurosurg 2005; 102: 998-1003
    CrossrefPubMedGoogle Scholar
  • 31 Dorhout Mees SM, van Dijk GW, Algra A et al. Glucose levels and outcome after subarachnoid hemorrhage. Neurology 2003; 61: 1132-1133
    CrossrefPubMedGoogle Scholar
  • #32 Tung P, Kopelnik A, Banki N et al. Predictors of neurocardiogenic injury after subarachnoid hemorrhage. Stroke 2004; 35: 548-551
    CrossrefPubMedGoogle Scholar
  • #33 Hasan D, Wijdicks EF, Vermeulen M. Hyponatremia is associated with cerebral ischemia in patients with aneurysmal subarachnoid hemorrhage. Ann Neurol 1990; 27: 106-108
    CrossrefPubMedGoogle Scholar
  • 34 Juvela S, Siironen J. D-dimer as an independent predictor for poor outcome after aneurysmal subarachnoid hemorrhage. Stroke 2006; 37: 1451-1456
    CrossrefPubMedGoogle Scholar
  • 35 Kissela BM, Sauerbeck L, Woo D et al. Subarachnoid hemorrhage: a preventable disease with a heritable component. Stroke 2002; 33: 1321-1326
    CrossrefPubMedGoogle Scholar
  • 36 Feigin VL, Rinkel GJ, Lawes CM et al. Risk factors for subarachnoid hemorrhage: an updated systematic review of epidemiological studies. Stroke 2005; 36: 2773-2780
    CrossrefPubMedGoogle Scholar
  • 37 Ruigrok YM, Buskens E, Rinkel GJ. Attributable risk of common and rare determinants of subarachnoid hemorrhage. Stroke 2001; 32: 1173-1175
    CrossrefPubMedGoogle Scholar
  • 38 Bonita R. Cigarette smoking, hypertension and the risk of subarachnoid hemorrhage: a population-based case-control study. Stroke 1986; 17: 831-835
    CrossrefPubMedGoogle Scholar
  • 39 Juvela S, Porras M, Poussa K. Natural history of unruptured intracranial aneurysms: probability of and risk factors for aneurysm rupture. J Neurosurg 2000; 93: 379-387
    CrossrefPubMedGoogle Scholar
  • 40 Wiebers DO, Whisnant JP, Huston 3rd J et al. Unruptured intracranial aneurysms: natural history, clinical outcome, and risks of surgical and endovascular treatment. Lancet 2003; 362: 103-110
    CrossrefPubMedGoogle Scholar
  • 41 Juvela S, Poussa K, Porras M. Factors affecting formation and growth of intracranial aneurysms: a long-term follow-up study. Stroke 2001; 32: 485-491
    CrossrefPubMedGoogle Scholar
  • 42 Juvela S, Hillbom M, Numminen H et al. Cigarette smoking and alcohol consumption as risk factors for aneurysmal subarachnoid hemorrhage. Stroke 1993; 24: 639-646
    CrossrefPubMedGoogle Scholar
  • 43 Longstreth Jr WT, Nelson LM, Koepsell TD et al. Cigarette smoking, alcohol use, and subarachnoid hemorrhage. Stroke 1992; 23: 1242-1249
    CrossrefPubMedGoogle Scholar
  • 44 Wermer MJ, van der Schaaf IC, Velthuis BK et al. Follow-up screening after subarachnoid haemorrhage: frequency and determinants of new aneurysms and enlargement of existing aneurysms. Brain 2005; 128: 2421-2429
    CrossrefPubMedGoogle Scholar
  • 45 Bor AS, Rinkel GJ, Adami J et al. Risk of subarachnoid haemorrhage according to number of affected relatives: a population based case-control study. Brain 2008; 131: 2662-2665
    CrossrefPubMedGoogle Scholar
  • 46 Wermer MJ, Koffijberg H, van der Schaaf IC. Effectiveness and costs of screening for aneurysms every 5 years after subarachnoid hemorrhage. Neurology 2008; 70: 2053-2062
    CrossrefPubMedGoogle Scholar
  • 47 van der Wee N, Rinkel GJ, Hasan D et al. Detection of subarachnoid haemorrhage on early CT: is lumbar puncture still needed after a negative scan?. J Neurol Neurosurg Psychiatry 1995; 58: 357-359
    CrossrefPubMedGoogle Scholar
  • #48 Fiebach JB, Schellinger PD, Gass A et al. Stroke magnetic resonance imaging is accurate in hyperacute intracerebral hemorrhage: a multicenter study on the validity of stroke imaging. Stroke 2004; 35: 502-506
    CrossrefPubMedGoogle Scholar
  • #49 Mitchell P, Wilkinson ID, Hoggard N et al. Detection of subarachnoid haemorrhage with magnetic resonance imaging. J Neurol Neurosurg Psychiatry 2001; 70: 205-211
    CrossrefPubMedGoogle Scholar
  • 50 Vermeulen M, van Gijn J. The diagnosis of subarachnoid haemorrhage. J Neurol Neurosurg Psychiatry 1990; 53: 365-372
    CrossrefPubMedGoogle Scholar
  • 51 Fifi JT, Meyers PM, Lavine SD et al. Complications of modern diagnostic cerebral angiography in an academic medical center. J Vasc Interv Radiol 2009; 20: 442-447
    CrossrefPubMedGoogle Scholar
  • 52 White PM, Teasdale EM, Wardlaw JM et al. Intracranial aneurysms: CT angiography and MR angiography for detection prospective blinded comparison in a large patient cohort. Radiology 2001; 219: 739-749
    CrossrefPubMedGoogle Scholar
  • 53 Dammert S, Krings T, Moller-Hartmann W et al. Detection of intracranial aneurysms with multislice CT: comparison with conventional angiography. Neuroradiology 2004; 46: 427-434
    PubMedGoogle Scholar
  • 54 Agid R, Andersson T, Almqvist H et al. Negative CT angiography findings in patients with spontaneous subarachnoid hemorrhage: When is digital subtraction angiography still needed?. AJNR Am J Neuroradiol 2010; 31: 696-705
    CrossrefPubMedGoogle Scholar
  • 55 Sarker SJ, Heuschmann PU, Burger I et al. Predictors of survival after haemorrhagic stroke in a multi-ethnic population: the South London Stroke Register (SLSR). J Neurol Neurosurg Psychiatry 2008; 79: 260-265
    CrossrefPubMedGoogle Scholar
  • 56 Frontera JA, Fernandez A, Schmidt JM et al. Impact of nosocomial infectious complications after subarachnoid hemorrhage. Neurosurgery 2008; 62: 80-87 discussion 87
    CrossrefPubMedGoogle Scholar
  • 57 Wartenberg KE, Schmidt JM, Claassen J et al. Impact of medical complications on outcome after subarachnoid hemorrhage. Crit Care Med 2006; 34: 617-623 quiz 624
    CrossrefPubMedGoogle Scholar
  • 58 Bilotta F, Spinelli A, Giovannini F et al. The effect of intensive insulin therapy on infection rate, vasospasm, neurologic outcome, and mortality in neurointensive care unit after intracranial aneurysm clipping in patients with acute subarachnoid hemorrhage: a randomized prospective pilot trial. J Neurosurg Anesthesiol 2007; 19: 156-160
    CrossrefPubMedGoogle Scholar
  • 59 Dorhout Mees SM, Luitse MJ, van den Bergh WM et al. Fever after aneurysmal subarachnoid hemorrhage: relation with extent of hydrocephalus and amount of extravasated blood. Stroke 2008; 39: 2141-2143
    CrossrefPubMedGoogle Scholar
  • 60 Todd MM, Hindman BJ, Clarke WR et al. Mild intraoperative hypothermia during surgery for intracranial aneurysm. N Engl J Med 2005; 352: 135-145
    CrossrefPubMedGoogle Scholar
  • 61 Wijdicks EF, Vermeulen M, Murray GD et al. The effects of treating hypertension following aneurysmal subarachnoid hemorrhage. Clin Neurol Neurosurg 1990; 92: 111-117
    CrossrefPubMedGoogle Scholar
  • 62 Siironen J, Juvela S, Varis J et al. No effect of enoxaparin on outcome of aneurysmal subarachnoid hemorrhage: a randomized, double-blind, placebo-controlled clinical trial. J Neurosurg 2003; 99: 953-959
    CrossrefPubMedGoogle Scholar
  • 63 Juvela S, Siironen J, Varis J et al. Risk factors for ischemic lesions following aneurysmal subarachnoid hemorrhage. J Neurosurg 2005; 102: 194-201
    CrossrefPubMedGoogle Scholar
  • 64 Dickinson LD, Miller LD, Patel CP et al. Enoxaparin increases the incidence of postoperative intracranial hemorrhage when initiated preoperatively for deep venous thrombosis prophylaxis in patients with brain tumors. Neurosurgery 1998; 43: 1074-1081
    CrossrefPubMedGoogle Scholar
  • 65 Black PM, Baker MF, Snook CP. Experience with external pneumatic calf compression in neurology and neurosurgery. Neurosurgery 1986; 18: 440-444
    CrossrefPubMedGoogle Scholar
  • 66 Naccarato M, Chiodo Grandi F, Dennis M et al. Physical methods for preventing deep vein thrombosis in stroke. Cochrane Database Syst Rev 2010; CD001922
    PubMedGoogle Scholar
  • 67 Lacut K, Bressollette L, Le Gal G et al. Prevention of venous thrombosis in patients with acute intracerebral hemorrhage. Neurology 2005; 65: 865-869
    CrossrefPubMedGoogle Scholar
  • 68 Lin CL, Dumont AS, Lieu AS et al. Characterization of perioperative seizures and epilepsy following aneurysmal subarachnoid hemorrhage. J Neurosurg 2003; 99: 978-985
    CrossrefPubMedGoogle Scholar
  • 69 Claassen J, Jette N, Chum F et al. Electrographic seizures and periodic discharges after intracerebral hemorrhage. Neurology 2007; 69: 1356-1365
    CrossrefPubMedGoogle Scholar
  • 70 Butzkueven H, Evans AH, Pitman A et al. Onset seizures independently predict poor outcome after subarachnoid hemorrhage. Neurology 2000; 55: 1315-1320
    CrossrefPubMedGoogle Scholar
  • 71 Claassen J, Hirsch LJ, Frontera JA et al. Prognostic significance of continuous EEG monitoring in patients with poor-grade subarachnoid hemorrhage. Neurocrit Care 2006; 4: 103-112
    CrossrefPubMedGoogle Scholar
  • 72 Molyneux AJ, Kerr RS, Yu LM et al. International subarachnoid aneurysm trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomised comparison of effects on survival, dependency, seizures, rebleeding, subgroups, and aneurysm occlusion. Lancet 2005; 366: 809-817
    CrossrefPubMedGoogle Scholar
  • 73 Foy PM, Chadwick DW, Rajgopalan N et al. Do prophylactic anticonvulsant drugs alter the pattern of seizures after craniotomy?. J Neurol Neurosurg Psychiatry 1992; 55: 753-757
    CrossrefPubMedGoogle Scholar
  • 74 Rosengart AJ, Huo JD, Tolentino J et al. Outcome in patients with subarachnoid hemorrhage treated with antiepileptic drugs. J Neurosurg 2007; 107: 253-260
    CrossrefPubMedGoogle Scholar
  • 75 Feigin VL, Anderson N, Rinkel GJ et al. Corticosteroids for aneurysmal subarachnoid haemorrhage and primary intracerebral haemorrhage. Cochrane Database Syst Rev 2005; CD004583
    PubMedGoogle Scholar
  • 76 Katayama Y, Haraoka J, Hirabayashi H et al. A randomized controlled trial of hydrocortisone against hyponatremia in patients with aneurysmal subarachnoid hemorrhage. Stroke 2007; 38: 2373-2375
    CrossrefPubMedGoogle Scholar
  • 77 Ohkuma H, Tsurutani H, Suzuki S. Incidence and significance of early aneurysmal rebleeding before neurosurgical or neurological management. Stroke 2001; 32: 1176-1180
    CrossrefPubMedGoogle Scholar
  • 78 Hijdra A, Vermeulen M, van Gijn J et al. Rerupture of intracranial aneurysms: a clinicoanatomic study. J Neurosurg 1987; 67: 29-33
    CrossrefPubMedGoogle Scholar
  • 79 de Gans K, Nieuwkamp DJ, Rinkel GJ et al. Timing of aneurysm surgery in subarachnoid hemorrhage: a systematic review of the literature. Neurosurgery 2002; 50: 336-340 discussion 340–342
    CrossrefPubMedGoogle Scholar
  • 80 Laidlaw JD, Siu KH. Poor-grade aneurysmal subarachnoid hemorrhage: outcome after treatment with urgent surgery. Neurosurgery 2003; 53: 1275-1280 discussion 1280-1282
    CrossrefPubMedGoogle Scholar
  • 81 Molyneux A, Kerr R, Stratton I et al. International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial. Lancet 2002; 360: 1267-1274
    CrossrefPubMedGoogle Scholar
  • 82 Molyneux AJ, Kerr RS, Birks J et al. Risk of recurrent subarachnoid haemorrhage, death, or dependence and standardised mortality ratios after clipping or coiling of an intracranial aneurysm in the International Subarachnoid Aneurysm Trial (ISAT): long-term follow-up. Lancet Neurol 2009; 8: 427-433
    CrossrefPubMedGoogle Scholar
  • 83 Campi A, Ramzi N, Molyneux AJ et al. Retreatment of ruptured cerebral aneurysms in patients randomized by coiling or clipping in the International Subarachnoid Aneurysm Trial (ISAT). Stroke 2007; 38: 1538-1544
    CrossrefPubMedGoogle Scholar
  • 84 Mitchell P, Kerr R, Mendelow AD et al. Could late rebleeding overturn the superiority of cranial aneurysm coil embolization over clip ligation seen in the International Subarachnoid Aneurysm Trial?. J Neurosurg 2008; 108: 437-442
    CrossrefPubMedGoogle Scholar
  • 85 Choudhari KA, Ramachandran MS, McCarron MO et al. Aneurysms unsuitable for endovascular intervention: surgical outcome and management challenges over a 5-year period following International Subarachnoid Haemorrhage Trial (ISAT). Clin Neurol Neurosurg 2007; 109: 868-875
    CrossrefPubMedGoogle Scholar
  • 86 O’Kelly CJ, Kulkarni AV, Austin PC et al. The impact of therapeutic modality on outcomes following repair of ruptured intracranial aneurysms: an administrative data analysis. Clinical article. J Neurosurg 2010; 113: 795-801
    CrossrefPubMedGoogle Scholar
  • 87 Johnston SC, Dowd CF, Higashida RT et al. Predictors of rehemorrhage after treatment of ruptured intracranial aneurysms: the Cerebral Aneurysm Rerupture After Treatment (CARAT) study. Stroke 2008; 39: 120-125
    CrossrefPubMedGoogle Scholar
  • 88 Elijovich L, Higashida RT, Lawton MT et al. Predictors and outcomes of intraprocedural rupture in patients treated for ruptured intracranial aneurysms: the CARAT study. Stroke 2008; 39: 1501-1506
    CrossrefPubMedGoogle Scholar
  • 89 Guo XB, Fan YM, Zhang JN. HydroSoft coil versus HydroCoil for endovascular aneurysm occlusion study: a single center experience. Eur J Radiol 2011; 79: e42-e46
    CrossrefPubMedGoogle Scholar
  • 90 Geyik S, Ertugrul O, Yavuz K et al. Comparison of bioactive coils and bare platinum coils for treatment of intracranial aneurysms: a matched-pair analysis. J Neurosurg 2010; 112: 709-713
    CrossrefPubMedGoogle Scholar
  • #91 Rezek I, Mousan G, Wang Z et al. Coil Type Does Not Affect Angiographic Follow-Up Outcomes of Cerebral Aneurysm Coiling: A Systematic Review and Meta-Analysis. AJNR Am J Neuroradiol 2013; 34: 1769-1773
    CrossrefPubMedGoogle Scholar
  • 92 Roos YB, Rinkel GJ, Vermeulen M et al. Antifibrinolytic therapy for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev 2003; CD001245
    PubMedGoogle Scholar
  • 93 Hillman J, Fridriksson S, Nilsson O et al. Immediate administration of tranexamic acid and reduced incidence of early rebleeding after aneurysmal subarachnoid hemorrhage: a prospective randomized study. J Neurosurg 2002; 97: 771-778
    CrossrefPubMedGoogle Scholar
  • 94 Pickard JD, Kirkpatrick PJ, Melsen T et al. Potential role of NovoSeven in the prevention of rebleeding following aneurysmal subarachnoid haemorrhage. Blood Coagul Fibrinolysis 2000; 11 (Suppl. 01) S117-S120
    CrossrefPubMedGoogle Scholar
  • #95 Nussbaum ES, Janjua TM, Defillo A et al. Perioperative use of recombinant factor VII to prevent intraoperative aneurysm rupture in high risk patients: a preliminary safety evaluation. Neurocrit Care 2009; 10: 55-60
    CrossrefPubMedGoogle Scholar
  • 96 Heros RC. Acute hydrocephalus after subarachnoid hemorrhage. Stroke 1989; 20: 715-717
    CrossrefPubMedGoogle Scholar
  • 97 Bota DP, Lefranc F, Vilallobos HR et al. Ventriculostomy-related infections in critically ill patients: a 6-year experience. J Neurosurg 2005; 103: 468-472
    CrossrefPubMedGoogle Scholar
  • 98 Bailes JE, Spetzler RF, Hadley MN et al. Management morbidity and mortality of poor-grade aneurysm patients. J Neurosurg 1990; 72: 559-566
    CrossrefPubMedGoogle Scholar
  • 99 Huttner HB, Nagel S, Tognoni E et al. Intracerebral hemorrhage with severe ventricular involvement: lumbar drainage for communicating hydrocephalus. Stroke 2007; 38: 183-187
    CrossrefPubMedGoogle Scholar
  • 100 Dorhout Mees SM, Rinkel GJ, Feigin VL et al. Calcium antagonists for aneurysmal subarachnoid haemorrhage. Cochrane Database Syst Rev 2007; CD000277
    PubMedGoogle Scholar
  • 101 Pickard JD, Murray GD, Illingworth R et al. Effect of oral nimodipine on cerebral infarction and outcome after subarachnoid haemorrhage: British aneurysm nimodipine trial. BMJ 1989; 298: 636-642
    CrossrefPubMedGoogle Scholar
  • 102 Kasuya H, Onda H, Sasahara A et al. Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage. Neurosurgery 2005; 56: 895-902 discussion 895-902
    PubMedGoogle Scholar
  • 103 Barth M, Capelle HH, Weidauer S et al. Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. Stroke 2007; 38: 330-336
    CrossrefPubMedGoogle Scholar
  • #104 Sandercock P. ‘Yes’ or ‘no’ to routine statins after subarachnoid hemorrhage to prevent delayed cerebral ischaemia, vasospasm, and death? A cautionary tale of 2 meta-analyses. Stroke 2010; 41: e1-e2
    CrossrefPubMedGoogle Scholar
  • #105 Sillberg VA, Wells GA, Perry JJ. Do statins improve outcomes and reduce the incidence of vasospasm after aneurysmal subarachnoid hemorrhage: a meta-analysis. Stroke 2008; 39: 2622-2626
    CrossrefPubMedGoogle Scholar
  • 106 Vergouwen MD, Meijers JC, Geskus RB et al. Biologic effects of simvastatin in patients with aneurysmal subarachnoid hemorrhage: a double-blind, placebo-controlled randomized trial. J Cereb Blood Flow Metab 2009; 29: 1444-1453
    CrossrefPubMedGoogle Scholar
  • 107 Vergouwen MD, de Haan RJ, Vermeulen M et al. Effect of statin treatment on vasospasm, delayed cerebral ischemia, and functional outcome in patients with aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis update. Stroke 2010; 41: e47-e52
    CrossrefPubMedGoogle Scholar
  • 108 Dorhout Mees SM, Algra A, Vandertop WP et al. Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial. Lancet 2012; 380: 44-49
    CrossrefPubMedGoogle Scholar
  • 109 Kosnik EJ, Hunt WE. Postoperative hypertension in the management of patients with intracranial arterial aneurysms. J Neurosurg 1976; 45: 148-154
    PubMedGoogle Scholar
  • 110 Wartenberg KE, Parra A. CT and CT-perfusion findings of reversible leukoencephalopathy during triple-H therapy for symptomatic subarachnoid hemorrhage-related vasospasm. J Neuroimaging 2006; 16: 170-175
    CrossrefPubMedGoogle Scholar
  • #111 Kim YW, Lawson MF, Hoh BL. Nonaneurysmal subarachnoid hemorrhage: an update. Curr Atheroscler Rep 2012; 14: 328-334
    CrossrefPubMedGoogle Scholar
  • 112 Rinkel GJ, Wijdicks EF, Hasan D et al. Outcome in patients with subarachnoid haemorrhage and negative angiography according to pattern of haemorrhage on computed tomography. Lancet 1991; 338: 964-968
    CrossrefPubMedGoogle Scholar
  • 113 Flaherty ML, Haverbusch M, Kissela B et al. Perimesencephalic subarachnoid hemorrhage: incidence, risk factors, and outcome. J Stroke Cerebrovasc Dis 2005; 14: 267-271
    CrossrefPubMedGoogle Scholar
  • 114 Ruigrok YM, Rinkel GJ, Buskens E et al. Perimesencephalic hemorrhage and CT angiography: A decision analysis. Stroke 2000; 31: 2976-2983
    CrossrefPubMedGoogle Scholar
  • 115 Dawkins AA, Evans AL, Wattam J et al. Complications of cerebral angiography: a prospective analysis of 2 924 consecutive procedures. Neuroradiology 2007; 49: 753-759
    CrossrefPubMedGoogle Scholar
  • 116 Kaufmann TJ, Huston 3rd J, Mandrekar JN et al. Complications of diag­nostic cerebral angiography: evaluation of 19 826 consecutive patients. Radiology 2007; 243: 812-819
    CrossrefPubMedGoogle Scholar
  • 117 Huttner HB, Hartmann M, Kohrmann M et al. Repeated digital sub­straction angiography after perimesencephalic subarachnoid hemorrhage?. J Neuroradiol 2006; 33: 87-89
    CrossrefPubMedGoogle Scholar
  • #118 Ringelstein A, Mueller O, Timochenko O et al. Reangiography after perimesencephalic subarachnoid hemorrhage. Nervenarzt 2013; 84: 715-719
    CrossrefPubMedGoogle Scholar
  • 119 Hui FK, Tumialan LM, Tanaka T et al. Clinical differences between angiographically negative, diffuse subarachnoid hemorrhage and perimesencephalic subarachnoid hemorrhage. Neurocrit Care 2009; 11: 64-70
    CrossrefPubMedGoogle Scholar
  • 120 Kang DH, Park J, Lee SH et al. Does non-perimesencephalic type non-aneurysmal subarachnoid hemorrhage have a benign prognosis?. J Clin Neurosci 2009; 16: 904-908
    CrossrefPubMedGoogle Scholar
  • 121 Hsu W, Pradilla G, Garonzik IM et al. Pretruncal nonaneurysmal subarachnoid hemorrhage causing basilar artery vasospasm. Neurocrit Care 2010; 13: 256-260
    CrossrefPubMedGoogle Scholar
  • 122 Greebe P, Rinkel GJ. Life expectancy after perimesencephalic subarachnoid hemorrhage. Stroke 2007; 38: 1222-1224
    CrossrefPubMedGoogle Scholar
  • 123 Rinkel GJ, Wijdicks EF, Vermeulen M et al. The clinical course of perimesencephalic nonaneurysmal subarachnoid hemorrhage. Ann Neurol 1991; 29: 463-468
    CrossrefPubMedGoogle Scholar
  • 124 van der Schaaf IC, Velthuis BK, Gouw A et al. Venous drainage in perimesencephalic hemorrhage. Stroke 2004; 35: 1614-1618
    CrossrefPubMedGoogle Scholar
  • #125 Sonobe M, Yamazaki T, Yonekura M et al. Small unruptured intracranial aneurysm verification study: SUAVe study, Japan. Stroke 2010; 41: 1969-1977
    CrossrefPubMedGoogle Scholar
  • 126 International Study of Unruptured Intracranial Aneurysms Investigators . Unruptured intracranial aneurysms – risk of rupture and risks of surgical intervention. International Study of Unruptured Intracranial Aneurysms Investigators. N Engl J Med 1998; 339: 1725-1733
    CrossrefPubMedGoogle Scholar
  • 127 Juvela S, Porras M, Heiskanen O. Natural history of unruptured in­tracranial aneurysms: a long-term follow-up study. J Neurosurg 1993; 79: 174-182
    CrossrefPubMedGoogle Scholar
  • 128 Juvela S. Natural history of unruptured intracranial aneurysms: risks for aneurysm formation, growth, and rupture. Acta Neurochir Suppl 2002; 82: 27-30
    PubMedGoogle Scholar
  • #129 Morita A, Kirino T, Hashi K et al. The natural course of unruptured cerebral aneurysms in a Japanese cohort. N Engl J Med 2012; 366: 2474-2482
    CrossrefPubMedGoogle Scholar
  • 130 Bavinzski G, Talazoglu V, Killer M et al. Gross and microscopic histopathological findings in aneurysms of the human brain treated with Guglielmi detachable coils. J Neurosurg 1999; 91: 284-293
    CrossrefPubMedGoogle Scholar
  • 131 Raaymakers TW, Rinkel GJ, Limburg M et al. Mortality and morbidity of surgery for unruptured intracranial aneurysms: a meta-analysis. Stroke 1998; 29: 1531-1538
    CrossrefPubMedGoogle Scholar
  • #132 Pierot L, Barbe C, Spelle L. Endovascular treatment of very small unruptured aneurysms: rate of procedural complications, clinical outcome, and anatomical results. Stroke 2010; 41: 2855-2859
    CrossrefPubMedGoogle Scholar
  • #133 Shigematsu T, Fujinaka T, Yoshimine T et al. Endovascular Therapy for Asymptomatic Unruptured Intracranial Aneurysms: JR-NET and JR-NET2 Findings. Stroke 2013; 44: 2735-2742
    CrossrefPubMedGoogle Scholar
  • #134 Raymond J, Darsaut TE, Molyneux AJ. A trial on unruptured intracranial aneurysms (the TEAM trial): results, lessons from a failure and the necessity for clinical care trials. Trials 2011; 12: 64
    CrossrefPubMedGoogle Scholar
  • #135 Darsaut TE, Findlay JM, Raymond J. The design of the Canadian UnRuptured Endovascular versus Surgery (CURES) trial. Can J Neurol Sci 2011; 38: 236-241
    PubMedGoogle Scholar
  • #136 Macdonald RL, Higashida RT, Keller E et al. Clazosentan, an endothelin receptor antagonist, in patients with aneurysmal subarachnoid haemorrhage undergoing surgical clipping: a randomised, double-blind, placebo-controlled phase 3 trial (CONSCIOUS-2). Lancet Neurol 2011; 10: 618-625
    CrossrefPubMedGoogle Scholar
  • #137 Dreier JP, Major S, Manning A et al. Cortical spreading ischaemia is a novel process involved in ischaemic damage in patients with aneurysmal subarachnoid haemorrhage. Brain 2009; 132: 1866-1881
    CrossrefPubMedGoogle Scholar
  • #138 Dreier JP. The role of spreading depression, spreading depolarization and spreading ischemia in neurological disease. Nat Med 2011; 17: 439-447
    CrossrefPubMedGoogle Scholar
  • #139 Marigold R, Gunther A, Tiwari D et al. Antiepileptic drugs for the primary and secondary prevention of seizures after subarachnoid haemorrhage. Cochrane Database Syst Rev 2013; 6: CD008710
    PubMedGoogle Scholar
  • #140 Scott RB, Eccles F, Molyneux AJ et al. Improved cognitive outcomes with endovascular coiling of ruptured intracranial aneurysms: neuropsychological outcomes from the International Subarachnoid Aneurysm Trial (ISAT). Stroke 2010; 41: 1743-1747
    CrossrefPubMedGoogle Scholar
  • #141 Dankbaar JW, de Rooij NK, Velthuis BK et al. Diagnosing delayed cerebral ischemia with different CT modalities in patients with subarachnoid hemorrhage with clinical deterioration. Stroke 2009; 40: 3493-3498
    CrossrefPubMedGoogle Scholar
  • #142 Neumann-Haefelin T. Das inzidentelle Aneurysma: Wann behandeln – wann abwarten?. Journal für Neurologie, Neurochirurgie und Psychiatrie 2011; 12: 148-151
    PubMedGoogle Scholar
  • 143 Wermer MJ, Greebe P, Algra A et al. Incidence of recurrent subarachnoid hemorrhage after clipping for ruptured intracranial aneurysms.. Stroke 2005; 36: 2394-2399
    CrossrefPubMedGoogle Scholar
  • 144 Dennis LJ, Claassen J, Hirsch LJ et al. Nonconvulsive status epilepticus after subarachnoid hemorrhage.. Neurosurgery 2005; 51: 1136-1143
    PubMedGoogle Scholar