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Drug Res (Stuttg) 2015; 65(1): 40-45
DOI: 10.1055/s-0034-1371890
Original Article
© Georg Thieme Verlag KG Stuttgart · New York

Microwave Assisted Synthesis and Anti-Lipase Activity of Some New Fluorine-Containing Benzimidazoles

E. Menteşe
1   Department of Chemistry,Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey
,
F. Yilmaz
1   Department of Chemistry,Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey
,
S. Ülker
2   Department of Biology, Art and Science Faculty, Recep Tayyip Erdogan University, Rize, Turkey
,
B. Kahveci
3   Department of Nutrition and Dietetics, Faculty of Health Sciences, Karadeniz Technical University, Trabzon, Turkey
› Author Affiliations
Further Information

Publication History

received 08 January 2014

accepted 07 March 2014

Publication Date:
02 April 2014 (online)

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Abstract

In this study, a new series of fluorine containing benzimidazoles (4a–l) and bisbenzimidazoles (6a–c, 8) were synthesized by the reaction of o-phenylenediamines with iminoester hydrochlorides (3a–l, 7) in methanol under microwave irradiation. The structures of these newly synthesized compounds were identified by IR, 1H-NMR, 13C-NMR, mass spectroscopy and elemental analysis data. The synthesized compounds were screened for their pancreatic lipase activities. Our results indicate that the compounds 6a, 6b and 6c can serve as an anti-lipase agent. The compounds 6b and 6c inhibited pancreatic lipase activity by 84.03% and 97.49% at a concentration of 3 µg/mL, respectively.

Key words

microwave chemistry - fluorine chemistry - anti lipase activity - 2-substituted benzimidazoles - Orlistat
 

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