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Synthesis 2015; 47(20): 3212-3220
DOI: 10.1055/s-0034-1380453
DOI: 10.1055/s-0034-1380453
paper
Aryne-Mediated Arylation of the 3-Benzazepine Scaffold: One-Pot Synthesis of 1-Aryl-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines
Further Information
Publication History
Received: 10 February 2015
Accepted after revision: 05 May 2015
Publication Date:
09 July 2015 (online)
Abstract
The coupling of β-amino carbanions derived from 3-benzazepines with in situ generated arynes has been demonstrated as a convenient route for the direct synthesis of a variety of 1-aryl-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepines, including the biologically active drug molecule SCH 12679.
Supporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0034-1380453.
- Supporting Information
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