Horm Metab Res 2015; 47(01): 1-3
DOI: 10.1055/s-0034-1394453
Editorial
© Georg Thieme Verlag KG Stuttgart · New York

Creating a “Transcampus” in Diabetes Research Between King’s College London and the Technische Universität Dresden: Update on Islet Biology and Transplantation

S. R. Bornstein
1   Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
2   Diabetes and Nutritional Sciences, Hodgkin Building, Guy’s Campus, King’s College London, London, UK
5   German Center for Diabetes Research (DZD e.V.), Dresden, Germany
6   DFG Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany
,
S. A. Amiel
2   Diabetes and Nutritional Sciences, Hodgkin Building, Guy’s Campus, King’s College London, London, UK
,
F. Rubino
2   Diabetes and Nutritional Sciences, Hodgkin Building, Guy’s Campus, King’s College London, London, UK
,
G. Mingrone
1   Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
2   Diabetes and Nutritional Sciences, Hodgkin Building, Guy’s Campus, King’s College London, London, UK
3   Department of Internal Medicine, Catholic University, School of Medicine, Rome, Italy
,
V. Kamvissi
1   Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
2   Diabetes and Nutritional Sciences, Hodgkin Building, Guy’s Campus, King’s College London, London, UK
,
M. Solimena
4   Molecular Diabetology, Paul Langerhans Institute Dresden, TU Dresden
5   German Center for Diabetes Research (DZD e.V.), Dresden, Germany
,
E. Bonifacio
5   German Center for Diabetes Research (DZD e.V.), Dresden, Germany
6   DFG Research Center for Regenerative Therapies Dresden, Technische Universität Dresden, Dresden, Germany
,
P. Jones
2   Diabetes and Nutritional Sciences, Hodgkin Building, Guy’s Campus, King’s College London, London, UK
,
P. Schwarz
1   Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
,
A. L. Birkenfeld
1   Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
,
A. Behrens
1   Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
2   Diabetes and Nutritional Sciences, Hodgkin Building, Guy’s Campus, King’s College London, London, UK
8   CR-UK London Research Institute, London, UK
,
A. Barthel
1   Department of Medicine III, Universitätsklinikum Carl Gustav Carus an der Technischen Universität Dresden, Dresden, Germany
7   Endokrinologikum Ruhr, Bochum, Germany
,
R. Lechler
9   MRC Centre for Transplantation, King’s College London, Guy’s Hospital, London, UK
,
M. Peakman
10   Department of Immunobiology, King’s College London School of Medicine, London, UK
› Author Affiliations
Further Information

Publication History

Publication Date:
05 December 2014 (online)

 
  • References

  • 1 Ortega FJ, Fernández-Real JM. Inflammation in adipose tissue and fatty acid anabolism: when enough is enough!. Horm Metab Res 2013; 45: 1009-1019
  • 2 Gregor MF, Hotamisligil GS. Inflammatory mechanisms in obesity. Annu Rev Immunol 2011; 29: 415-445
  • 3 Donath MY. Targeting inflammation in the treatment of type 2 diabetes: time to start. Nat Rev Drug Discov 2014; 13: 465-476
  • 4 Bornstein SR, Licinio J. Improving the efficacy of translational medicine by optimally integrating health care, academia and industry. Nat Med 2011; 17: 1567-1569
  • 5 Ludwig B, Reichel A, Kruppa A, Ludwig S, Steffen A, Weitz J, Bornstein SR. Islet transplantation at the Dresden Diabetes Center: five years’ experience. Horm Metab Res 2014; 47: 4-8
  • 6 Ludwig B, Barthel A, Reichel A, Block NL, Ludwig S, Schally AV, Bornstein SR. Modulation of the pancreatic islet-stress axis as a novel potential therapeutic target in diabetes mellitus. Vitam Horm 2014; 95: 195-222
  • 7 Byrne ML, Hopkins D, Littlejohn W, Beckford R, Srinivasan P, Heaton N, Amiel SA, Choudhary P. Outcomes for adults with type 1 diabetes referred with severe hypoglycaemia and/or referred for islettransplantation to a specialist hypoglycaemia service. Horm Metab Res 2014; 47: 9-15
  • 8 Marathe CS, Drogemuller CJ, Marathe JA, Loudavaris T, Hawthorne WJ, O’Connell PJ, Radford T, Kay TW, Horowitz M, Coates PT, Torpy DJ. Islet cell transplantation in Australia: screening, remote transplantation, and incretin hormone secretion in insulin independent patients. Horm Metab Res 2014; 47: 16-23
  • 9 Ludwig B, Zimerman B, Steffen A, Yavriants K, Azarov D, Reichel A, Vardi P, German T, Shabtay N, Rotem A, Evron Y, Neufeld T, Mimon S, Ludwig S, Brendel MD, Bornstein SR, Barkai U. A novel device for islet transplantation providing immune protection and oxygen supply. Horm Metab Res 2010; 42: 918-922
  • 10 Ludwig B, Reichel A, Steffen A, Zimerman B, Schally AV, Block NL, Colton CK, Ludwig S, Kersting S, Bonifacio E, Solimena M, Gendler Z, Rotem A, Barkai U, Bornstein SR. Transplantation of human islets without immunosuppression. Proc Natl Acad Sci U S A 2013; 110: 19054-19058
  • 11 Evron Y, Zimermann B, Ludwig B, Barkai U, Colton CK, Weir GC, Arieli B, Maimon S, Shalev N, Yavriyants K, Goldman T, Gendler Z, Eizen L, Vardi P, Bloch K, Barthel A, Bornstein S, Rotem A. Oxygen supply by photosynthesis to an implantable islet cell device. Horm Metab Res 2014; 47: 24-30
  • 12 Reichart B, Niemann H, Chavakis T, Denner J, Jaeckel E, Ludwig B, Marckmann G, Schnieke A, Schwinzer R, Seissler J, Tönjes RR, Klymiuk N, Wolf E, Bornstein SR. Xenotransplantation of porcine islet cells as a potential option for the treatment of type 1 diabetes in the future. Horm Metab Res 2014; 47: 31-35
  • 13 Kourtzelis I, Ferreira A, Mitroulis I, Ricklin D, Bornstein SR, Waskow C, Lambris JD, Chavakis T. Complement inhibition in a xenogeneic model of interactions between human whole blood and porcine endothelium. Horm Metab Res 2014; 47: 36-42
  • 14 Rahmig S, Bornstein SR, Chavakis T, Jaeckel E, Waskow C. Humanized mouse models for type 1 diabetes including pancreatic islet transplantation. Horm Metab Res 2014; 47: 43-47
  • 15 Theil A, Wilhelm C, Guhr E, Reinhardt J, Bonifacio E. The relative merits of cord blood as a cell source for autologous T regulatory cell therapy in type 1 diabetes. Horm Metab Res 2014; 47: 48-55
  • 16 Hauge-Evans AC, King AJ, Carmignac D, Richardson CC, Robinson ICAF, Low MJ, Christie MR, Persaud SJ, Jones PM. Somatostatin secreted by islet delta-cells fulfills multiple roles as a paracrine regulator of islet function. Diabetes 2009; 58: 403-411
  • 17 Richardson CC, To K, Foot VL, Hauge-Evans AC, Carmignac D, Christie MR. Increased perinatal remodelling of the pancreas in somatostatin-deficient mice: potential role of transforming growth factor-beta signalling in regulating beta cell growth in early life. Horm Metab Res 2014; 47: 56-63
  • 18 Drynda R, Peters C, Jones P, Bowe J. The role of non-placental signals in the adaptation of islets to pregnancy. Horm Metab Res 2014; 47: 64-71
  • 19 Zhao M, Choudhary P, Srinivasan P, Tang H, Heaton N, Fung M, Barthel A, Bornstein SR, Amiel SA, Huang GC. Modification of human islet preparation: an effective approach to improve graft outcome after islet transplantation?. Horm Metab Res 2014; 47: 72-77
  • 20 King AJ, Clarkin CE, Austin AL, Ajram L, Dhunna JK, Jamil MO, Ditta SI, Ibrahim S, Raza Z, Jones PM. ALK5 inhibition maintains islet endothelial cell survival but does not enhance islet graft revascularisation or function. Horm Metab Res 2014; 47: 78-83
  • 21 Horie A, Tokuyama Y, Ishizuka T, Suzuki Y, Marumo K, Oshikiri K, Ide K, Sunaga M, Kanatsuka A. The dipeptidyl peptidase-4 inhibitor vildagliptin has the capacity to repair β-cell dysfunction and insulin resistance. Horm Metab Res 2014; 46: 814-818
  • 22 Kamvissi V, Salerno A, Bornstein SR, Mingrone G, Rubino F. Incretins or anti-incretins? A new model for the “entero-pancreatic axis”. Horm Metab Res 2014; 47: 84-87