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ZWR - Das Deutsche Zahnärzteblatt 2014; 123(12): 594-600
DOI: 10.1055/s-0034-1395623
Wissenschaft – Prophylaxe
© Georg Thieme Verlag KG Stuttgart · New York

Auswirkungen einer Mundspüllösung mit 0,2% PVP-VA+Hyaluronsäure+0,09% CHX gegenüber einer 0,2% Chlorhexidin, alkoholfreien Mundspüllösung auf bakterielle Plaque-Kontrolle ohne weitere Maßnahmen der Mundhygiene – Randomisierte, crossover, dreifachblind klinische Studie

Randomized, crossover, triple blind clinical trial to compare the effects of a mouthwash containing 0.2% PVP VA+Hyaluronic acid+0.09% CHX versus a 0.2% chlorhexidine, alcohol-free mouthwash on bacterial plaque control in the absence of oral hygiene maneuvers
T. Weinstein
1   Mailand, Italien
,
R. Weinstein
1   Mailand, Italien
› Author Affiliations
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Publication History

Publication Date:
07 January 2015 (online)

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Das Ziel der Studie ist es, eine alkoholfreie Mundspüllösung mit 0,2% PVP-VA+Hyaluronsäure+0,09% CHX+ADS mit einer 0,2% alkoholfreien Chlorhexidin-Mundspüllösung hinsichtlich der Wirkung gegen die Bildung und das Wachstum des bakteriellen Biofilms ohne weitere Maßnahmen zur Mundhygiene zu vergleichen. 50 Patienten nahmen an der klinischen Studie teil. Die Patienten wurden nach der Zufallsliste 2 Gruppen zugewiesen: Gruppe A: 10 ml Mundwasser mit 0,2% alkoholfreiem PVP-VA; Gruppe B: 10 ml Mundwasser mit 0,2% alkoholfreiem Chlorhexidin. Die Patienten wurden gebeten, für 14 Tage 2-mal täglich Mundspülung anzuwenden. Die Patienten in beiden Gruppen wurden dazu verpflichtet, auf jegliche mechanische Maßnahme zur Mundhygiene während der 2 Wochen, in denen sie die Mundspülung durchführten, zu verzichten. An Tag 14, am Ende der Aufnahme der klinischen Daten des Plaque-Index (PI), Gingival-Index (GI), Pigmentierungs-Index (Stain-Index, SI) und subjektiver Parameter, bekamen alle Patienten in beiden Gruppen eine neue professionelle Dentalhygiene-Behandlung, um die Protokollvariablen wieder zurückzusetzen. Nach einer Auswaschungswoche begannen die Patienten, die 2. Mundspülung zu verwenden, die nicht während des 1. Zyklus verwendet wurde. Die statistische Analyse wies nach, dass es keine signifikanten Unterschiede zwischen Mundspüllösung Chlorhexidin 0,2% und Mundspüllösung PVP-VA 0,2% beim PI oder GI gab, weder in der 1. noch in der 2. Woche. Hinsichtlich des SI gibt es einen Unterschied bei beiden Gruppen, statistisch signifikant sowohl in der 1. als auch der 2. Woche. Die gewonnenen Daten weisen nach, dass die PVP-VA-Mundspüllösung bis 0,2% eine signifikant niedrigere Verfärbung zum Ergebnis hat als die Mundspüllösung mit Chlorhexidin 0,2%. Schlussfolgernd weist die PVP-VA-Mundspüllösung eine des CHX 0,2% bei der Verhinderung von Plaque und der Vorbeugung von Gingivitis ähnliche Aktivität auf und führt zu einer geringeren Bildung von Zahnverfärbungen.

The aim of the study is to compare an alcohol-free mouthwash containing 0.2% PVP VA, Hyaluronic acid+0.09% CHX+ADS vs. a 0.2% alcohol-free chlorhexidine mouthwash in countering the formation and growth of the bacterial biofilm in the absence of oral hygiene maneuvers. 50 patients were enrolled for the clinical trial. The patients were assigned to 2 groups according to the randomization list in: Group A: 10 mL of mouthwash containing 0.2% alcohol-free PVP VA, Hyaluronic Acid, ADS and 0.09 Chlorhexidine; Group B: 10 mL of mouthwash containing 0.2% alcohol-free Chlorhexidine. Patients were asked to use mouthrinses twice daily, for 14 days. The patients in both groups were required to refrain from all mechanical oral hygiene practices during the 2 weeks in which the mouthwash is used. On day 14, at the end of clinical data recording of Plaque Index, Gingival Index, Stain Index and subjective parameters, all patients in both groups received a new professional dental hygiene session in order to reset the protocol variables again. After one wash-out week, patients started using the second mouthrinse that was not used during the first cycle. From the statistical analysis, there were no statistically significant differences between mouthwash chlorhexidine 0.2% and mouthwash PVP-VA 0.2% for the Plaque Index and Gingival Index, both at the first week or at the second. Regarding the index of pigmentation (Stain Index), there is a difference between the 2 groups, statistically significant in both the first and the second week. From the data obtained, the PVP-VA mouthwash to 0.2% resulted in a significantly lower formation of pigmentation than that with Chlorhexidine 0.2%. In conclusion, PVPVA 0.2% mouthrinse demonstrates a similar activity in respect to a CHX 0.2% in inhibiting plaque and preventing gingivitis. PVPVA 0.2% mouthrinse ADS leads to lower formation of tooth staining in respect to a conventional CHX 0.2% mouthrinse.

Schlüsselwörter

Mundspüllösung - PVP-VA - Biofilmprävention - anti-plaque - Chlorhexidin - Hyaluronsäure

Key words

mouthrinse - PVP-VA - biofilm prevention - anti-plaque - chlorhexidine - hyaluronic acid
 

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