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Synlett 2016; 27(18): 2616-2620
DOI: 10.1055/s-0035-1562526
DOI: 10.1055/s-0035-1562526
letter
Transition-Metal-Free Direct Arylation and Esterification Reaction of Unprotected Indolylcarboxylic Acid Derivatives: A New Entry to 2-(1H-Indol-2-yl)-5-(phenylthio)-1,3,4-oxadiazoles and Aryl 1H-Indole-2-carboxylates
Further Information
Publication History
Received: 06 May 2016
Accepted after revision: 04 July 2016
Publication Date:
01 August 2016 (online)
Abstract
An efficient, ligand-free, transition-metal-free, direct arylation and esterification reaction of unprotected indolylcarboxylic acid derivatives with diaryliodonium salts was developed, thus providing a new entry to 2-(1H-indol-2-yl)-5-(phenylthio)-1,3,4-oxadiazole and aryl 1H-indole-2-carboxylate derivatives with good yields.
Keywords
arylation - diaryliodonium salts - indolylcarboxylic acids - esterification - transition-metal-freeSupporting Information
- Supporting information for this article is available online at http://dx.doi.org/10.1055/s-0035-1562526.
- Supporting Information
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