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Synfacts 2016; 12(09): 0897
DOI: 10.1055/s-0035-1562570
Synthesis of Heterocycles
© Georg Thieme Verlag Stuttgart · New York

Synthesis of Palbociclib: An SNAr Reaction on a Kilogram Scale

Contributor(s):
Victor Snieckus
,
John M. Curto (Pfizer)
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Publication History

Publication Date:
18 August 2016 (online)

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Key words

SNAr reaction - coupling reaction - Grignard reagents - kinase inhibitors - medicinal chemistry