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Semin Respir Crit Care Med 2016; 37(03): 441-456
DOI: 10.1055/s-0036-1582451
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Current Approach to Diagnosis and Management of Pulmonary Eosinophilic Syndromes: Eosinophilic Pneumonias, Eosinophilic Granulomatosis with Polyangiitis, and Hypereosinophilic Syndrome

Amen Sergew
1   Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colorado
,
Evans R. Fernández Pérez
1   Division of Pulmonary and Critical Care Medicine, National Jewish Health, Denver, Colorado
› Author Affiliations
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Publication History

Publication Date:
27 May 2016 (online)

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Abstract

Eosinophils play a key role in orchestrating the complex clinicopathological pulmonary and extrapulmonary disease features in patients with eosinophilic syndromes. Eosinophilic pulmonary syndromes consist of a heterogeneous group of disorders characterized by the presence of peripheral blood eosinophilia and/or eosinophilic-related pulmonary impairment. These disorders can present with varying degrees of organ involvement, and while their presentation may be similar, it is important to define the disease state, as management and prognosis differ. In this article, we discuss acute and chronic eosinophilic pneumonias, eosinophilic granulomatosis with polyangiitis, and the hypereosinophilic syndromes. The mainstay of therapy for these disorders has been corticosteroids; however, recent and ongoing studies have provided strong grounds for optimism for specific targeted treatment approaches.

Keywords

eosinophilic lung diseases - acute eosinophilic pneumonia - chronic eosinophilic pneumonia - eosinophilic granulomatosis with polyangiitis - Churg–Strauss syndrome - allergic granulomatosis and angiitis - hypereosinophilic syndromes
 

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