Total Syntheses of Urgineanins A, B, D, and Their Analogues

Abstract

The first asymmetric total syntheses of urgineanins A, B, and D – potent antiproliferative homoisoflavonoids – were achieved by utilizing Pd-catalyzed allylic substitution of the allylic acetate with arylboronic acids for introduction of the C rings of homoisoflavonoid skeleton. Several unnatural urgineanin analogues were also prepared in this manner.

Keywords

homoisoflavonoid - natural product - Pd catalysis - allylic arylation - anticancer agent

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