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Synthesis 2018; 50(01): 170-174
DOI: 10.1055/s-0036-1589111
DOI: 10.1055/s-0036-1589111
paper
Trichloroisocyanuric Acid as an Efficient Reagent for the Synthesis of Phosphoroamidates via Atherton–Todd Reaction under Base-Free Conditions
The authors gratefully acknowledge support from the Institute for Advanced Studies in Basic Sciences (IASBS) Research Council under grant No. G2016IASBS31101.Further Information
Publication History
Received: 04 July 2017
Accepted after revision: 29 August 2017
Publication Date:
12 September 2017 (online)
Abstract
A simple, efficient, and novel method is developed for the synthesis of phosphoroamidates via an Atherton–Todd coupling reaction of amines with dialkyl H-phosphite using trichloroisocyanuric acid as an efficient and safe reagent. Treatment of amines with dialkyl H-phosphite and trichloroisocyanuric acid under base-free conditions gives phosphoroamidates in moderate to good yields. The reaction proceeded effectively to afford the corresponding phosphoroamidates via a dehydrogenative coupling of H-phosphonates with amines. This method is easy, rapid, and good-yielding for the synthesis of phosphoroamidates.
Supporting Information
- Supporting information for this article is available online at https://doi.org/10.1055/s-0036-1589111.
- Supporting Information
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